DegronMD - Q8NBR9(NDUFV1-DT)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L39M	TCGA-51-4080	LUSC	TCGA	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.2222
p.L39M	DO26441	LUSC	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.2222
p.L47I	TCGA-AX-A0J0	UCEC	TCGA	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.7174
p.L47I	DO35589	PBCA	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.7174
p.L47I	DO41133	UCEC	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.7174
p.S45I	TCGA-EE-A2GI	SKCM	TCGA	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.623
p.S45I	DO37410	SKCM	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.623
p.R35S	TCGA-MV-A51V	BLCA	TCGA	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.1111
p.R35S	DO474	BLCA	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.1111
p.R33Q	TCGA-W3-AA1Q	SKCM	TCGA	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.0556
p.R33Q	DO219487	SKCM	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.0556
p.H56Q	DO222404	BTCA	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.1944
p.H56P	ACH-000955	Colon/Colorectal Cancer	CCLE	PRSLLCSIS	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons