DegronMD

Uniprot ID: Q8NBR9

Source protein: Uncharacterized protein NDUFV1-DT

Source gene: NDUFV1-DT

Class: DEG_APCC_DBOX_1

Location: 43:51

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7515

ASA_SCORE: 46.7333

COIL: 0.4281

CONS_SCORE: 0

DSS_SCORE: 0.3916

HELIX: 0.1387

FCONS_SCORE: 0

RIG_SCORE: 0.6993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L39M	TCGA-51-4080	LUSC	TCGA	PRSLLCSIS	DEG_APCC_DBOX_1	0.2222
p.L39M	DO26441	LUSC	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	0.2222
p.L47I	TCGA-AX-A0J0	UCEC	TCGA	PRSLLCSIS	DEG_APCC_DBOX_1	0.7174
p.L47I	DO35589	PBCA	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	0.7174
p.L47I	DO41133	UCEC	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	0.7174
p.S45I	TCGA-EE-A2GI	SKCM	TCGA	PRSLLCSIS	DEG_APCC_DBOX_1	0.623
p.S45I	DO37410	SKCM	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	0.623
p.R35S	TCGA-MV-A51V	BLCA	TCGA	PRSLLCSIS	DEG_APCC_DBOX_1	0.1111
p.R35S	DO474	BLCA	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	0.1111
p.R33Q	TCGA-W3-AA1Q	SKCM	TCGA	PRSLLCSIS	DEG_APCC_DBOX_1	0.0556
p.R33Q	DO219487	SKCM	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	0.0556
p.H56Q	DO222404	BTCA	ICGC	PRSLLCSIS	DEG_APCC_DBOX_1	0.1944
p.H56P	ACH-000955	Colon/Colorectal Cancer	CCLE	PRSLLCSIS	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NBR9	Uncharacterized protein NDUFV1-DT	DEG_APCC_DBOX_1	43:51	PRSLLCSIS	APC,CDC20,FZR1	0.7515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons