DegronMD - Q8NBS3(SLC4A11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A296V	TCGA-69-7979	LUAD	TCGA	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation rewiring degron network	0.25
p.A296V	TCGA-CK-5913	COAD	TCGA	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation rewiring degron network	0.25
p.Q287K	DO229018	LICA	ICGC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation altering degron motif	0.5833
p.R286I	DO45513	LUSC	ICGC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation altering degron motif	0.8102
p.E276Q	DO27468	LUSC	ICGC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation rewiring degron network	0.0833
p.E275D	DO47299	SKCM	ICGC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation rewiring degron network	0.0556
p.P299S	DO37406	SKCM	ICGC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation rewiring degron network	0.1667
p.T298M	SIDM02020	Esophageal Carcinoma	GDSC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation rewiring degron network	0.1944
p.R297H	SIDM00217	Colorectal Carcinoma	GDSC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation rewiring degron network	0.2222
p.R297H	ACH-000999	Colon/Colorectal Cancer	CCLE	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation rewiring degron network	0.2222
p.R297H	SNU-1040	large intestine	COSMIC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation rewiring degron network	0.2222
p.A292V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation altering degron motif	0.6936
p.A292V	ACH-001127	Leukemia	CCLE	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation altering degron motif	0.6936
p.A292V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation altering degron motif	0.6936
p.G286A	T47D	breast	COSMIC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation altering degron motif	0.754
p.R289H	Farage	haematopoietic and lymphoid tissue	COSMIC	QRQLLTMVS	DEG_APCC_DBOX_1	285:293	Mutation altering degron motif	0.8244

Kaplan plot for SLC4A11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC4A11

UniProt ID: Q8NBS3

Entrez ID: 83959

Protein name: Solute carrier family 4 member 11 (Sodium borate cotransporter 1) (NaBC1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC4A11 in