DegronMD

Uniprot ID: Q8NBS3

Source protein: Solute carrier family 4 member 11

Source gene: SLC4A11

Class: DEG_APCC_DBOX_1

Location: 285:293

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9897

ASA_SCORE: 66.5778

COIL: 0.4407

CONS_SCORE: 0.4573

DSS_SCORE: 0.4215

HELIX: 0.543

FCONS_SCORE: 1.0826

RIG_SCORE: 0.7644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A296V	TCGA-69-7979	LUAD	TCGA	QRQLLTMVS	DEG_APCC_DBOX_1	0.25
p.A296V	TCGA-CK-5913	COAD	TCGA	QRQLLTMVS	DEG_APCC_DBOX_1	0.25
p.Q287K	DO229018	LICA	ICGC	QRQLLTMVS	DEG_APCC_DBOX_1	0.5833
p.R286I	DO45513	LUSC	ICGC	QRQLLTMVS	DEG_APCC_DBOX_1	0.8102
p.E276Q	DO27468	LUSC	ICGC	QRQLLTMVS	DEG_APCC_DBOX_1	0.0833
p.E275D	DO47299	SKCM	ICGC	QRQLLTMVS	DEG_APCC_DBOX_1	0.0556
p.P299S	DO37406	SKCM	ICGC	QRQLLTMVS	DEG_APCC_DBOX_1	0.1667
p.T298M	SIDM02020	Esophageal Carcinoma	GDSC	QRQLLTMVS	DEG_APCC_DBOX_1	0.1944
p.R297H	SIDM00217	Colorectal Carcinoma	GDSC	QRQLLTMVS	DEG_APCC_DBOX_1	0.2222
p.R297H	ACH-000999	Colon/Colorectal Cancer	CCLE	QRQLLTMVS	DEG_APCC_DBOX_1	0.2222
p.R297H	SNU-1040	large_intestine	COSMIC	QRQLLTMVS	DEG_APCC_DBOX_1	0.2222
p.A292V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	QRQLLTMVS	DEG_APCC_DBOX_1	0.6936
p.A292V	ACH-001127	Leukemia	CCLE	QRQLLTMVS	DEG_APCC_DBOX_1	0.6936
p.A292V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	QRQLLTMVS	DEG_APCC_DBOX_1	0.6936
p.G286A	T47D	breast	COSMIC	QRQLLTMVS	DEG_APCC_DBOX_1	0.754
p.R289H	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	QRQLLTMVS	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NBS3	Solute carrier family 4 member 11	DEG_APCC_DBOX_1	285:293	QRQLLTMVS	APC,CDC20,FZR1	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons