DegronMD - Q8NBU5(ATAD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L223F	TCGA-BR-8059	STAD	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation altering degron motif	0.6981
p.D221N	TCGA-CV-7414	HNSC	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation altering degron motif	0.5821
p.M217I	TCGA-DI-A1BU	UCEC	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation altering degron motif	0.6507
p.M217I	DO42023	UCEC	ICGC	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation altering degron motif	0.6507
p.M217L	TCGA-FG-6690	LGG	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation altering degron motif	0.5999
p.M217L	DO22141	LGG	ICGC	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation altering degron motif	0.5999
p.W220C	TCGA-L9-A444	LUAD	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation altering degron motif	0.7
p.W220C	DO26015	LUAD	ICGC	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation altering degron motif	0.7
p.F216C	TCGA-QS-A5YQ	UCEC	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation altering degron motif	0.7108
p.F216C	DO49073	UCEC	ICGC	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation altering degron motif	0.7108
p.M211I	SIDM01120	Other Solid Cancers	GDSC	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation rewiring degron network	0.1944
p.M211I	ACH-002174	Lung Cancer	CCLE	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation rewiring degron network	0.1944
p.M211I	NCI-H720	lung	COSMIC	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation rewiring degron network	0.1944
p.M211T	SIDM00429	B-Lymphoblastic Leukemia	GDSC	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation rewiring degron network	0.1944
p.M211T	NALM-6	haematopoietic and lymphoid tissue	COSMIC	FMSLWDGL	DEG_MDM2_SWIB_1	216:223	Mutation rewiring degron network	0.1944

Kaplan plot for ATAD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATAD1

UniProt ID: Q8NBU5

Entrez ID: 84896

Protein name: Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATAD1 in