DegronMD

Uniprot ID: Q8NBU5

Source protein: Outer mitochondrial transmembrane helix translocase

Source gene: ATAD1

Class: DEG_MDM2_SWIB_1

Location: 216:223

E3 ligase: MDM2

DEGRON score: 0.8208

ASA_SCORE: 34.9625

COIL: 0.3714

CONS_SCORE: 0.7301

DSS_SCORE: 0.2262

HELIX: 0.6084

FCONS_SCORE: 1.3096

RIG_SCORE: 0.7851

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L223F	TCGA-BR-8059	STAD	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	0.6981
p.D221N	TCGA-CV-7414	HNSC	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	0.5821
p.M217I	TCGA-DI-A1BU	UCEC	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	0.6507
p.M217I	DO42023	UCEC	ICGC	FMSLWDGL	DEG_MDM2_SWIB_1	0.6507
p.M217L	TCGA-FG-6690	LGG	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	0.5999
p.M217L	DO22141	LGG	ICGC	FMSLWDGL	DEG_MDM2_SWIB_1	0.5999
p.W220C	TCGA-L9-A444	LUAD	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	0.7
p.W220C	DO26015	LUAD	ICGC	FMSLWDGL	DEG_MDM2_SWIB_1	0.7
p.F216C	TCGA-QS-A5YQ	UCEC	TCGA	FMSLWDGL	DEG_MDM2_SWIB_1	0.7108
p.F216C	DO49073	UCEC	ICGC	FMSLWDGL	DEG_MDM2_SWIB_1	0.7108
p.M211I	SIDM01120	Other Solid Cancers	GDSC	FMSLWDGL	DEG_MDM2_SWIB_1	0.1944
p.M211I	ACH-002174	Lung Cancer	CCLE	FMSLWDGL	DEG_MDM2_SWIB_1	0.1944
p.M211I	NCI-H720	lung	COSMIC	FMSLWDGL	DEG_MDM2_SWIB_1	0.1944
p.M211T	SIDM00429	B-Lymphoblastic Leukemia	GDSC	FMSLWDGL	DEG_MDM2_SWIB_1	0.1944
p.M211T	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	FMSLWDGL	DEG_MDM2_SWIB_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NBU5	Outer mitochondrial transmembrane helix translocase	DEG_MDM2_SWIB_1	216:223	FMSLWDGL	MDM2	0.8208	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons