DegronMD - Q8NCA9(ZNF784)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T54M	TCGA-EO-A22S	UCEC	TCGA	TDTTLVPEP	DEG_COP1_1	51:59	Mutation altering degron motif	0.6312
p.T54M	DO41590	UCEC	ICGC	TDTTLVPEP	DEG_COP1_1	51:59	Mutation altering degron motif	0.6312
p.T51M	TCGA-EO-A22U	UCEC	TCGA	TDTTLVPEP	DEG_COP1_1	51:59	Mutation altering degron motif	0.7423
p.T51M	DO43755	UCEC	ICGC	TDTTLVPEP	DEG_COP1_1	51:59	Mutation altering degron motif	0.7423
p.P62T	DO50678	ORCA	ICGC	TDTTLVPEP	DEG_COP1_1	51:59	Mutation rewiring degron network	0.25
p.P62T	DO27893	ORCA	ICGC	TDTTLVPEP	DEG_COP1_1	51:59	Mutation rewiring degron network	0.25
p.S64Y	DO227933	PBCA	ICGC	TDTTLVPEP	DEG_COP1_1	51:59	Mutation rewiring degron network	0.1944
p.A68S	SIDM00965	Small Cell Lung Carcinoma	GDSC	TDTTLVPEP	DEG_COP1_1	51:59	Mutation rewiring degron network	0.0833
p.A68S	ACH-000800	Lung Cancer	CCLE	TDTTLVPEP	DEG_COP1_1	51:59	Mutation rewiring degron network	0.0833
p.A68S	NCI-H446	lung	COSMIC	TDTTLVPEP	DEG_COP1_1	51:59	Mutation rewiring degron network	0.0833
p.P59T	SIDM01132	Other Solid Cancers	GDSC	TDTTLVPEP	DEG_COP1_1	51:59	Mutation altering degron motif	0.7031
p.P59T	PFSK-1	central nervous system	COSMIC	TDTTLVPEP	DEG_COP1_1	51:59	Mutation altering degron motif	0.7031
p.S64C	SIDM00485	Oral Cavity Carcinoma	GDSC	TDTTLVPEP	DEG_COP1_1	51:59	Mutation rewiring degron network	0.1944
p.S64C	ACH-000794	Head and Neck Cancer	CCLE	TDTTLVPEP	DEG_COP1_1	51:59	Mutation rewiring degron network	0.1944
p.S64C	BICR22	upper aerodigestive tract	COSMIC	TDTTLVPEP	DEG_COP1_1	51:59	Mutation rewiring degron network	0.1944

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons