DegronMD

Uniprot ID: Q8NCA9

Source protein: Zinc finger protein 784

Source gene: ZNF784

Class: DEG_COP1_1

Location: 51:59

E3 ligase: COP1

DEGRON score: 0.7822

ASA_SCORE: 74.6222

COIL: 0.6263

CONS_SCORE: 0.9311

DSS_SCORE: 0.4315

HELIX: 0.0046

FCONS_SCORE: 0.9547

RIG_SCORE: 0.7616

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T54M	TCGA-EO-A22S	UCEC	TCGA	TDTTLVPEP	DEG_COP1_1	0.6312
p.T54M	DO41590	UCEC	ICGC	TDTTLVPEP	DEG_COP1_1	0.6312
p.T51M	TCGA-EO-A22U	UCEC	TCGA	TDTTLVPEP	DEG_COP1_1	0.7423
p.T51M	DO43755	UCEC	ICGC	TDTTLVPEP	DEG_COP1_1	0.7423
p.P62T	DO50678	ORCA	ICGC	TDTTLVPEP	DEG_COP1_1	0.25
p.P62T	DO27893	ORCA	ICGC	TDTTLVPEP	DEG_COP1_1	0.25
p.S64Y	DO227933	PBCA	ICGC	TDTTLVPEP	DEG_COP1_1	0.1944
p.A68S	SIDM00965	Small Cell Lung Carcinoma	GDSC	TDTTLVPEP	DEG_COP1_1	0.0833
p.A68S	ACH-000800	Lung Cancer	CCLE	TDTTLVPEP	DEG_COP1_1	0.0833
p.A68S	NCI-H446	lung	COSMIC	TDTTLVPEP	DEG_COP1_1	0.0833
p.P59T	SIDM01132	Other Solid Cancers	GDSC	TDTTLVPEP	DEG_COP1_1	0.7031
p.P59T	PFSK-1	central_nervous_system	COSMIC	TDTTLVPEP	DEG_COP1_1	0.7031
p.S64C	SIDM00485	Oral Cavity Carcinoma	GDSC	TDTTLVPEP	DEG_COP1_1	0.1944
p.S64C	ACH-000794	Head and Neck Cancer	CCLE	TDTTLVPEP	DEG_COP1_1	0.1944
p.S64C	BICR22	upper_aerodigestive_tract	COSMIC	TDTTLVPEP	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCA9	Zinc finger protein 784	DEG_COP1_1	51:59	TDTTLVPEP	COP1	0.7822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons