DegronMD - Q8NCE0(TSEN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G184C	TCGA-AX-A063	UCEC	TCGA	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778
p.G184C	DO42201	UCEC	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778
p.C199Y	TCGA-BF-A3DM	SKCM	TCGA	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.C199Y	DO48667	SKCM	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.C199F	DO222707	BTCA	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.C192Y	DO230309	COCA	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.5976
p.T202A	DO229013	COCA	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1111
p.Q194H	DO234326	ESAD	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.647
p.D185Y	DO229028	LICA	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.3056
p.D176N	DO230961	LUSC	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0556
p.D176N	DO224594	LUSC	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0556
p.G196V	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778
p.R187L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8428
p.R187L	ACH-000951	Lung Cancer	CCLE	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8428
p.R187L	NCI-H2342	lung	COSMIC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8428
p.R187P	SIDM01590	Breast Carcinoma	GDSC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7512
p.L186F	CAL-148	breast	COSMIC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.6981
p.L186F	CAL-78	bone	COSMIC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.6981
p.V199M	GCIY	stomach	COSMIC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.V199M	ME-1	haematopoietic and lymphoid tissue	COSMIC	PREPLGCLQ	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944

Kaplan plot for TSEN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSEN2

UniProt ID: Q8NCE0

Entrez ID: 80746

Protein name: tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TSEN2 in