DegronMD

Uniprot ID: Q8NCE0

Source protein: tRNA-splicing endonuclease subunit Sen2

Source gene: TSEN2

Class: DEG_APCC_DBOX_1

Location: 186:194

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6461

ASA_SCORE: 80.1778

COIL: 0.6773

CONS_SCORE: 0.2351

DSS_SCORE: 0.5795

HELIX: 0.2041

FCONS_SCORE: 0.6852

RIG_SCORE: 0.6802

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G184C	TCGA-AX-A063	UCEC	TCGA	PREPLGCLQ	DEG_APCC_DBOX_1	0.2778
p.G184C	DO42201	UCEC	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	0.2778
p.C199Y	TCGA-BF-A3DM	SKCM	TCGA	PREPLGCLQ	DEG_APCC_DBOX_1	0.1944
p.C199Y	DO48667	SKCM	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	0.1944
p.C199F	DO222707	BTCA	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	0.1944
p.C192Y	DO230309	COCA	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	0.5976
p.T202A	DO229013	COCA	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	0.1111
p.Q194H	DO234326	ESAD	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	0.647
p.D185Y	DO229028	LICA	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	0.3056
p.D176N	DO230961	LUSC	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	0.0556
p.D176N	DO224594	LUSC	ICGC	PREPLGCLQ	DEG_APCC_DBOX_1	0.0556
p.G196V	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PREPLGCLQ	DEG_APCC_DBOX_1	0.2778
p.R187L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PREPLGCLQ	DEG_APCC_DBOX_1	0.8428
p.R187L	ACH-000951	Lung Cancer	CCLE	PREPLGCLQ	DEG_APCC_DBOX_1	0.8428
p.R187L	NCI-H2342	lung	COSMIC	PREPLGCLQ	DEG_APCC_DBOX_1	0.8428
p.R187P	SIDM01590	Breast Carcinoma	GDSC	PREPLGCLQ	DEG_APCC_DBOX_1	0.7512
p.L186F	CAL-148	breast	COSMIC	PREPLGCLQ	DEG_APCC_DBOX_1	0.6981
p.L186F	CAL-78	bone	COSMIC	PREPLGCLQ	DEG_APCC_DBOX_1	0.6981
p.V199M	GCIY	stomach	COSMIC	PREPLGCLQ	DEG_APCC_DBOX_1	0.1944
p.V199M	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	PREPLGCLQ	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCE0	tRNA-splicing endonuclease subunit Sen2	DEG_APCC_DBOX_1	186:194	PREPLGCLQ	APC,CDC20,FZR1	0.6461	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons