DegronMD - Q8NCJ5(SPRYD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L368P	TCGA-2Z-A9JQ	KIRP	TCGA	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation altering degron motif	0.6471
p.L368P	DO219684	KIRP	ICGC	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation altering degron motif	0.6471
p.E376D	TCGA-A5-A0G2	UCEC	TCGA	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1944
p.E376D	DO41235	UCEC	ICGC	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1944
p.R360W	TCGA-B5-A0JR	UCEC	TCGA	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1667
p.R360W	DO41791	UCEC	ICGC	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1667
p.E381Q	TCGA-BT-A0YX	BLCA	TCGA	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.0556
p.E381Q	DO516	BLCA	ICGC	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.0556
p.E378K	TCGA-BT-A0YX	BLCA	TCGA	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1389
p.E378K	DO516	BLCA	ICGC	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1389
p.E371K	TCGA-CV-7097	HNSC	TCGA	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation altering degron motif	0.7022
p.E371K	DO14886	HNSC	ICGC	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation altering degron motif	0.7022
p.E377D	TCGA-DU-6392	LGG	TCGA	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1667
p.E377D	DO22237	LGG	ICGC	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1667
p.H369Q	DO229038	LICA	ICGC	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation altering degron motif	0.7582
p.D379H	ACH-000989	Colon/Colorectal Cancer	CCLE	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1111
p.D379H	SNU-175	large intestine	COSMIC	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1111
p.P369S	ACH-001751	Sarcoma	CCLE	MYLHQE	LIG_APCC_ABBA_1	366:371	Mutation altering degron motif	0.6752

Kaplan plot for SPRYD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPRYD3

UniProt ID: Q8NCJ5

Entrez ID: 84926

Protein name: SPRY domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPRYD3 in