DegronMD

Uniprot ID: Q8NCJ5

Source protein: SPRY domain-containing protein 3

Source gene: SPRYD3

Class: LIG_APCC_ABBA_1

Location: 366:371

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6978

ASA_SCORE: 43.3833

COIL: 0.3248

CONS_SCORE: 0.5884

DSS_SCORE: 0.5813

HELIX: 0.0313

FCONS_SCORE: 1.0879

RIG_SCORE: 0.7303

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L368P	TCGA-2Z-A9JQ	KIRP	TCGA	MYLHQE	LIG_APCC_ABBA_1	0.6471
p.L368P	DO219684	KIRP	ICGC	MYLHQE	LIG_APCC_ABBA_1	0.6471
p.E376D	TCGA-A5-A0G2	UCEC	TCGA	MYLHQE	LIG_APCC_ABBA_1	0.1944
p.E376D	DO41235	UCEC	ICGC	MYLHQE	LIG_APCC_ABBA_1	0.1944
p.R360W	TCGA-B5-A0JR	UCEC	TCGA	MYLHQE	LIG_APCC_ABBA_1	0.1667
p.R360W	DO41791	UCEC	ICGC	MYLHQE	LIG_APCC_ABBA_1	0.1667
p.E381Q	TCGA-BT-A0YX	BLCA	TCGA	MYLHQE	LIG_APCC_ABBA_1	0.0556
p.E381Q	DO516	BLCA	ICGC	MYLHQE	LIG_APCC_ABBA_1	0.0556
p.E378K	TCGA-BT-A0YX	BLCA	TCGA	MYLHQE	LIG_APCC_ABBA_1	0.1389
p.E378K	DO516	BLCA	ICGC	MYLHQE	LIG_APCC_ABBA_1	0.1389
p.E371K	TCGA-CV-7097	HNSC	TCGA	MYLHQE	LIG_APCC_ABBA_1	0.7022
p.E371K	DO14886	HNSC	ICGC	MYLHQE	LIG_APCC_ABBA_1	0.7022
p.E377D	TCGA-DU-6392	LGG	TCGA	MYLHQE	LIG_APCC_ABBA_1	0.1667
p.E377D	DO22237	LGG	ICGC	MYLHQE	LIG_APCC_ABBA_1	0.1667
p.H369Q	DO229038	LICA	ICGC	MYLHQE	LIG_APCC_ABBA_1	0.7582
p.D379H	ACH-000989	Colon/Colorectal Cancer	CCLE	MYLHQE	LIG_APCC_ABBA_1	0.1111
p.D379H	SNU-175	large_intestine	COSMIC	MYLHQE	LIG_APCC_ABBA_1	0.1111
p.P369S	ACH-001751	Sarcoma	CCLE	MYLHQE	LIG_APCC_ABBA_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCJ5	SPRY domain-containing protein 3	LIG_APCC_ABBA_1	366:371	MYLHQE	APC,CDC20,FZR1	0.6978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons