DegronMD - Q8NCN5(PDPR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F816C	TCGA-06-0646	GBM	TCGA	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation rewiring degron network	0.1944
p.F816C	DO13791	GBM	ICGC	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation rewiring degron network	0.1944
p.T824A	TCGA-17-Z032	LUAD	TCGA	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation altering degron motif	0.7139
p.V829G	TCGA-D3-A51T	SKCM	TCGA	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation rewiring degron network	0.25
p.V829G	DO47389	SKCM	ICGC	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation rewiring degron network	0.25
p.T824M	TCGA-EO-A3AY	UCEC	TCGA	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation altering degron motif	0.7423
p.T824M	DO222492	COCA	ICGC	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation altering degron motif	0.7423
p.T824M	DO43202	UCEC	ICGC	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation altering degron motif	0.7423
p.N819S	DO51973	CLLE	ICGC	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation rewiring degron network	0.2778
p.C813F	DO50859	LIRI	ICGC	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation rewiring degron network	0.1111
p.NR836NW	DO222402	MELA	ICGC	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation rewiring degron network	0
p.N819H	SIDM00690	Head and Neck Carcinoma	GDSC	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation rewiring degron network	0.2778
p.G815S	ACH-001841	Bile Duct Cancer	CCLE	SEDTGE	DEG_Kelch_Keap1_1	821:826	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons