DegronMD

Uniprot ID: Q8NCN5

Source protein: Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

Source gene: PDPR

Class: DEG_Kelch_Keap1_1

Location: 821:826

E3 ligase: KEAP1

DEGRON score: 0.5368

ASA_SCORE: 80.4833

COIL: 0.8415

CONS_SCORE: 0.2292

DSS_SCORE: 0.1962

HELIX: 0.1082

FCONS_SCORE: 0.6472

RIG_SCORE: 0.7762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F816C	TCGA-06-0646	GBM	TCGA	SEDTGE	DEG_Kelch_Keap1_1	0.1944
p.F816C	DO13791	GBM	ICGC	SEDTGE	DEG_Kelch_Keap1_1	0.1944
p.T824A	TCGA-17-Z032	LUAD	TCGA	SEDTGE	DEG_Kelch_Keap1_1	0.7139
p.V829G	TCGA-D3-A51T	SKCM	TCGA	SEDTGE	DEG_Kelch_Keap1_1	0.25
p.V829G	DO47389	SKCM	ICGC	SEDTGE	DEG_Kelch_Keap1_1	0.25
p.T824M	TCGA-EO-A3AY	UCEC	TCGA	SEDTGE	DEG_Kelch_Keap1_1	0.7423
p.T824M	DO222492	COCA	ICGC	SEDTGE	DEG_Kelch_Keap1_1	0.7423
p.T824M	DO43202	UCEC	ICGC	SEDTGE	DEG_Kelch_Keap1_1	0.7423
p.N819S	DO51973	CLLE	ICGC	SEDTGE	DEG_Kelch_Keap1_1	0.2778
p.C813F	DO50859	LIRI	ICGC	SEDTGE	DEG_Kelch_Keap1_1	0.1111
p.NR836NW	DO222402	MELA	ICGC	SEDTGE	DEG_Kelch_Keap1_1	0
p.N819H	SIDM00690	Head and Neck Carcinoma	GDSC	SEDTGE	DEG_Kelch_Keap1_1	0.2778
p.G815S	ACH-001841	Bile Duct Cancer	CCLE	SEDTGE	DEG_Kelch_Keap1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCN5	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial	DEG_Kelch_Keap1_1	821:826	SEDTGE	KEAP1	0.5368	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons