DegronMD - Q8NCV1(ADAD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A207T	TCGA-2G-AAEW	TGCT	TCGA	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.1667
p.R192C	TCGA-49-AAR3	LUAD	TCGA	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.3056
p.R192C	DO218919	LUAD	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.3056
p.R192C	DO32932	PACA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.3056
p.R204C	TCGA-AH-6897	READ	TCGA	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.25
p.R204C	DO36773	READ	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.25
p.V202I	DO233652	GACA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.3056
p.P206S	DO222731	MELA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.1944
p.P206S	DO37432	SKCM	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.1944
p.P195S	DO30550	OV	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation altering degron motif	0.5641
p.R211H	DO32992	PACA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.0556
p.R211H	DO35198	PACA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.0556
p.R194W	DO224782	PACA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation altering degron motif	0.8634
p.P189T	DO37835	SKCM	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.2222
p.A198P	DO41927	UCEC	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation altering degron motif	0.6392
p.E184D	DO41361	UCEC	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.0833
p.L193M	SIDM00507	Other Solid Cancers	GDSC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation altering degron motif	0.711
p.L193M	COR-L321	NS	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation altering degron motif	0.711
p.E209D	ACH-000366	Neuroblastoma	CCLE	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.1111
p.E209D	SK-N-DZ	autonomic ganglia	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.1111
p.P186L	ACH-000837	Lung Cancer	CCLE	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.1389
p.P186L	NCI-H322M	lung	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.1389
p.S188Y	ACH-002109	Bone Cancer	CCLE	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.1944
p.S188Y	ES8	bone	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.1944
p.P195A	ACH-002164	Pancreatic Cancer	CCLE	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation altering degron motif	0.6392
p.P195A	MZ1-PC	pancreas	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation altering degron motif	0.6392
p.S188I	SNG-M	endometrium	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.1944
p.E203D	SNU-81	large intestine	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	193:201	Mutation rewiring degron network	0.2778

Kaplan plot for ADAD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAD2

UniProt ID: Q8NCV1

Entrez ID: 161931

Protein name: Adenosine deaminase domain-containing protein 2 (Testis nuclear RNA-binding protein-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAD2 in