DegronMD

Uniprot ID: Q8NCV1

Source protein: Adenosine deaminase domain-containing protein 2

Source gene: ADAD2

Class: DEG_APCC_DBOX_1

Location: 193:201

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6881

ASA_SCORE: 83.6667

COIL: 0.9236

CONS_SCORE: 0.4975

DSS_SCORE: 0.5311

HELIX: 0.0467

FCONS_SCORE: 0.7745

RIG_SCORE: 0.6635

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A207T	TCGA-2G-AAEW	TGCT	TCGA	SRPPLAPLS	DEG_APCC_DBOX_1	0.1667
p.R192C	TCGA-49-AAR3	LUAD	TCGA	SRPPLAPLS	DEG_APCC_DBOX_1	0.3056
p.R192C	DO218919	LUAD	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.3056
p.R192C	DO32932	PACA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.3056
p.R204C	TCGA-AH-6897	READ	TCGA	SRPPLAPLS	DEG_APCC_DBOX_1	0.25
p.R204C	DO36773	READ	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.25
p.V202I	DO233652	GACA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.3056
p.P206S	DO222731	MELA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.1944
p.P206S	DO37432	SKCM	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.1944
p.P195S	DO30550	OV	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.5641
p.R211H	DO32992	PACA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.0556
p.R211H	DO35198	PACA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.0556
p.R194W	DO224782	PACA	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.8634
p.P189T	DO37835	SKCM	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.2222
p.A198P	DO41927	UCEC	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.6392
p.E184D	DO41361	UCEC	ICGC	SRPPLAPLS	DEG_APCC_DBOX_1	0.0833
p.L193M	SIDM00507	Other Solid Cancers	GDSC	SRPPLAPLS	DEG_APCC_DBOX_1	0.711
p.L193M	COR-L321	NS	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	0.711
p.E209D	ACH-000366	Neuroblastoma	CCLE	SRPPLAPLS	DEG_APCC_DBOX_1	0.1111
p.E209D	SK-N-DZ	autonomic_ganglia	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	0.1111
p.P186L	ACH-000837	Lung Cancer	CCLE	SRPPLAPLS	DEG_APCC_DBOX_1	0.1389
p.P186L	NCI-H322M	lung	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	0.1389
p.S188Y	ACH-002109	Bone Cancer	CCLE	SRPPLAPLS	DEG_APCC_DBOX_1	0.1944
p.S188Y	ES8	bone	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	0.1944
p.P195A	ACH-002164	Pancreatic Cancer	CCLE	SRPPLAPLS	DEG_APCC_DBOX_1	0.6392
p.P195A	MZ1-PC	pancreas	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	0.6392
p.S188I	SNG-M	endometrium	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	0.1944
p.E203D	SNU-81	large_intestine	COSMIC	SRPPLAPLS	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRPPLAPLS

Degron related mutations and impact score

Drug responses associated with ADAD2 mutations

All proteins holding degron of SRPPLAPLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCV1	Adenosine deaminase domain-containing protein 2	DEG_APCC_DBOX_1	193:201	SRPPLAPLS	APC,CDC20,FZR1	0.6881	More...