DegronMD - Q8NCY6(MSANTD4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D179N	TCGA-AJ-A5DW	UCEC	TCGA	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0556
p.D179N	DO8264	COAD	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0556
p.D179N	DO50075	UCEC	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0556
p.V205L	TCGA-CR-7371	HNSC	TCGA	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0833
p.V205L	DO15454	HNSC	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0833
p.T188I	TCGA-D3-A2JH	SKCM	TCGA	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation blocking phosphorylation signal	0.75
p.T188I	DO47263	SKCM	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation blocking phosphorylation signal	0.75
p.R195I	TCGA-E6-A1M0	UCEC	TCGA	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation altering degron motif	0.6991
p.R195I	DO43682	UCEC	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation altering degron motif	0.6991
p.H182D	TCGA-RW-A685	PCPG	TCGA	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.1389
p.L203F	DO233945	GACA	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.1389
p.V205I	SIDM00957	Colorectal Carcinoma	GDSC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0833
p.N206D	SIDM00556	Neuroblastoma	GDSC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0556
p.N206D	ACH-000227	Neuroblastoma	CCLE	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0556
p.N206D	KP-N-YN	autonomic ganglia	COSMIC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0556
p.F186V	SIDM00214	Colorectal Carcinoma	GDSC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.25
p.F186V	ACH-000955	Colon/Colorectal Cancer	CCLE	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.25
p.F186V	SNU-407	large intestine	COSMIC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.25
p.F180L	SIDM00982	Glioblastoma	GDSC	LNSTPSRS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MSANTD4

UniProt ID: Q8NCY6

Entrez ID: 84437

Protein name: Myb/SANT-like DNA-binding domain-containing protein 4 (Myb/SANT-like DNA-binding domain containing 4 with coiled-coils)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MSANTD4 in