DegronMD

Uniprot ID: Q8NCY6

Source protein: Myb/SANT-like DNA-binding domain-containing protein 4

Source gene: MSANTD4

Class: DEG_SCF_FBW7_1

Location: 189:196

E3 ligase: FBXW7

DEGRON score: 0.991

ASA_SCORE: 73.325

COIL: 0.7996

CONS_SCORE: 0.4944

DSS_SCORE: 0.3969

HELIX: 0.1121

FCONS_SCORE: 0.9013

RIG_SCORE: 0.6591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D179N	TCGA-AJ-A5DW	UCEC	TCGA	LNSTPSRS	DEG_SCF_FBW7_1	0.0556
p.D179N	DO8264	COAD	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	0.0556
p.D179N	DO50075	UCEC	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	0.0556
p.V205L	TCGA-CR-7371	HNSC	TCGA	LNSTPSRS	DEG_SCF_FBW7_1	0.0833
p.V205L	DO15454	HNSC	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	0.0833
p.T188I	TCGA-D3-A2JH	SKCM	TCGA	LNSTPSRS	DEG_SCF_FBW7_1	0.75
p.T188I	DO47263	SKCM	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	0.75
p.R195I	TCGA-E6-A1M0	UCEC	TCGA	LNSTPSRS	DEG_SCF_FBW7_1	0.6991
p.R195I	DO43682	UCEC	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	0.6991
p.H182D	TCGA-RW-A685	PCPG	TCGA	LNSTPSRS	DEG_SCF_FBW7_1	0.1389
p.L203F	DO233945	GACA	ICGC	LNSTPSRS	DEG_SCF_FBW7_1	0.1389
p.V205I	SIDM00957	Colorectal Carcinoma	GDSC	LNSTPSRS	DEG_SCF_FBW7_1	0.0833
p.N206D	SIDM00556	Neuroblastoma	GDSC	LNSTPSRS	DEG_SCF_FBW7_1	0.0556
p.N206D	ACH-000227	Neuroblastoma	CCLE	LNSTPSRS	DEG_SCF_FBW7_1	0.0556
p.N206D	KP-N-YN	autonomic_ganglia	COSMIC	LNSTPSRS	DEG_SCF_FBW7_1	0.0556
p.F186V	SIDM00214	Colorectal Carcinoma	GDSC	LNSTPSRS	DEG_SCF_FBW7_1	0.25
p.F186V	ACH-000955	Colon/Colorectal Cancer	CCLE	LNSTPSRS	DEG_SCF_FBW7_1	0.25
p.F186V	SNU-407	large_intestine	COSMIC	LNSTPSRS	DEG_SCF_FBW7_1	0.25
p.F180L	SIDM00982	Glioblastoma	GDSC	LNSTPSRS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCY6	Myb/SANT-like DNA-binding domain-containing protein 4	DEG_SCF_FBW7_1	189:196	LNSTPSRS	FBXW7	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons