DegronMD - Q8NDB2(BANK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R604W	TCGA-AA-3815	COAD	TCGA	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1111
p.R610T	TCGA-DD-AADB	LIHC	TCGA	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.2778
p.E626K	TCGA-EE-A29D	SKCM	TCGA	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1389
p.E626K	ACH-002396	Bone Cancer	CCLE	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1389
p.E626K	Sarc9371	bone	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1389
p.P612S	TCGA-EE-A29E	SKCM	TCGA	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation altering degron motif	0.6752
p.T627A	TCGA-QC-A7B5	SARC	TCGA	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1111
p.N605S	DO2813	BRCA	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1389
p.P613S	DO9002	COAD	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation altering degron motif	0.6752
p.N605D	DO10172	COAD	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1389
p.V628L	DO229036	LICA	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.0833
p.G615C	DO229041	LICA	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation altering degron motif	0.76
p.H611R	DO27011	LUSC	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.3056
p.P613L	DO220897	MELA	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation altering degron motif	0.7582
p.E622K	DO37831	SKCM	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.25
p.I607T	SIDM00216	Colorectal Carcinoma	GDSC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1944
p.I607T	ACH-000989	Colon/Colorectal Cancer	CCLE	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1944
p.I607T	SNU-175	large intestine	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1944
p.T615K	SIDM00504	Glioma	GDSC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation altering degron motif	0.7306
p.T615K	ACH-001126	Brain Cancer	CCLE	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation altering degron motif	0.7306
p.T615K	MOG-G-UVW	central nervous system	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation altering degron motif	0.7306
p.R604L	SIDM00781	Colorectal Carcinoma	GDSC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1111
p.R604L	SIDM00780	Colorectal Carcinoma	GDSC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1111
p.R604L	SNU-C2B	large intestine	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1111
p.P611L	SIDM01463	Endometrial Carcinoma	GDSC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.3056
p.P611L	ACH-000397	Endometrial/Uterine Cancer	CCLE	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.3056
p.H612Y	RPMI-6666	haematopoietic and lymphoid tissue	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation altering degron motif	0.7229
p.E611K	Sarc9371	bone	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.3056
p.Y604C	TE-11	oesophagus	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1111
p.A610V	639-V	urinary tract	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.2778
p.C620Y	SNG-M	endometrium	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.3056
p.A625V	639-V	urinary tract	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	612:619	Mutation rewiring degron network	0.1667

Kaplan plot for BANK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BANK1

UniProt ID: Q8NDB2

Entrez ID: 55024

Protein name: B-cell scaffold protein with ankyrin repeats

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BANK1 in