DegronMD

Uniprot ID: Q8NDB2

Source protein: B-cell scaffold protein with ankyrin repeats

Source gene: BANK1

Class: DEG_SCF_FBW7_1

Location: 612:619

E3 ligase: FBXW7

DEGRON score: 0.9834

ASA_SCORE: 96.7875

COIL: 0.9671

CONS_SCORE: 0.4625

DSS_SCORE: 0.7334

HELIX: 0.0138

FCONS_SCORE: 1.12

RIG_SCORE: 0.5879

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R604W	TCGA-AA-3815	COAD	TCGA	PAPTPRPT	DEG_SCF_FBW7_1	0.1111
p.R610T	TCGA-DD-AADB	LIHC	TCGA	PAPTPRPT	DEG_SCF_FBW7_1	0.2778
p.E626K	TCGA-EE-A29D	SKCM	TCGA	PAPTPRPT	DEG_SCF_FBW7_1	0.1389
p.E626K	ACH-002396	Bone Cancer	CCLE	PAPTPRPT	DEG_SCF_FBW7_1	0.1389
p.E626K	Sarc9371	bone	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	0.1389
p.P612S	TCGA-EE-A29E	SKCM	TCGA	PAPTPRPT	DEG_SCF_FBW7_1	0.6752
p.T627A	TCGA-QC-A7B5	SARC	TCGA	PAPTPRPT	DEG_SCF_FBW7_1	0.1111
p.N605S	DO2813	BRCA	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	0.1389
p.P613S	DO9002	COAD	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	0.6752
p.N605D	DO10172	COAD	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	0.1389
p.V628L	DO229036	LICA	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	0.0833
p.G615C	DO229041	LICA	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	0.76
p.H611R	DO27011	LUSC	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	0.3056
p.P613L	DO220897	MELA	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	0.7582
p.E622K	DO37831	SKCM	ICGC	PAPTPRPT	DEG_SCF_FBW7_1	0.25
p.I607T	SIDM00216	Colorectal Carcinoma	GDSC	PAPTPRPT	DEG_SCF_FBW7_1	0.1944
p.I607T	ACH-000989	Colon/Colorectal Cancer	CCLE	PAPTPRPT	DEG_SCF_FBW7_1	0.1944
p.I607T	SNU-175	large_intestine	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	0.1944
p.T615K	SIDM00504	Glioma	GDSC	PAPTPRPT	DEG_SCF_FBW7_1	0.7306
p.T615K	ACH-001126	Brain Cancer	CCLE	PAPTPRPT	DEG_SCF_FBW7_1	0.7306
p.T615K	MOG-G-UVW	central_nervous_system	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	0.7306
p.R604L	SIDM00781	Colorectal Carcinoma	GDSC	PAPTPRPT	DEG_SCF_FBW7_1	0.1111
p.R604L	SIDM00780	Colorectal Carcinoma	GDSC	PAPTPRPT	DEG_SCF_FBW7_1	0.1111
p.R604L	SNU-C2B	large_intestine	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	0.1111
p.P611L	SIDM01463	Endometrial Carcinoma	GDSC	PAPTPRPT	DEG_SCF_FBW7_1	0.3056
p.P611L	ACH-000397	Endometrial/Uterine Cancer	CCLE	PAPTPRPT	DEG_SCF_FBW7_1	0.3056
p.H612Y	RPMI-6666	haematopoietic_and_lymphoid_tissue	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	0.7229
p.E611K	Sarc9371	bone	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	0.3056
p.Y604C	TE-11	oesophagus	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	0.1111
p.A610V	639-V	urinary_tract	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	0.2778
p.C620Y	SNG-M	endometrium	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	0.3056
p.A625V	639-V	urinary_tract	COSMIC	PAPTPRPT	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PAPTPRPT

Degron related mutations and impact score

Drug responses associated with BANK1 mutations

All proteins holding degron of PAPTPRPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDB2	B-cell scaffold protein with ankyrin repeats	DEG_SCF_FBW7_1	612:619	PAPTPRPT	FBXW7	0.9834	More...