DegronMD - Q8NDG6(TDRD9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T126P	TCGA-B5-A1MR	UCEC	TCGA	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.0833
p.T126P	DO41758	UCEC	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.0833
p.R110W	TCGA-EO-A22X	UCEC	TCGA	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.8634
p.R110W	DO43907	UCEC	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.8634
p.P109L	DO50970	LICA	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6471
p.S117R	DO232835	NACA	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7427
p.T125A	DO232852	NACA	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1111
p.P103S	DO229224	THCA	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1667
p.P111Q	DO229240	THCA	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.5924
p.P111L	SIDM01117	Small Cell Lung Carcinoma	GDSC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6471
p.S105N	SIDM00120	Prostate Carcinoma	GDSC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.2222
p.S105N	ACH-000979	Prostate Cancer	CCLE	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.2222
p.S105N	DU-145	prostate	COSMIC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.2222
p.P123Q	SIDM00656	Burkitt's Lymphoma	GDSC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1667
p.P123Q	ACH-000944	Lymphoma	CCLE	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1667
p.P123Q	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1667
p.R100Q	SUP-B15	haematopoietic and lymphoid tissue	COSMIC	PRPSLAKLS	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.0833

Kaplan plot for TDRD9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TDRD9

UniProt ID: Q8NDG6

Entrez ID: 122402

Protein name: ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TDRD9 in