DegronMD

Uniprot ID: Q8NDG6

Source protein: ATP-dependent RNA helicase TDRD9

Source gene: TDRD9

Class: DEG_APCC_DBOX_1

Location: 109:117

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7231

ASA_SCORE: 83.3222

COIL: 0.735

CONS_SCORE: 0.3691

DSS_SCORE: 0.49

HELIX: 0.2312

FCONS_SCORE: 0.9541

RIG_SCORE: 0.6723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T126P	TCGA-B5-A1MR	UCEC	TCGA	PRPSLAKLS	DEG_APCC_DBOX_1	0.0833
p.T126P	DO41758	UCEC	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	0.0833
p.R110W	TCGA-EO-A22X	UCEC	TCGA	PRPSLAKLS	DEG_APCC_DBOX_1	0.8634
p.R110W	DO43907	UCEC	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	0.8634
p.P109L	DO50970	LICA	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	0.6471
p.S117R	DO232835	NACA	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	0.7427
p.T125A	DO232852	NACA	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	0.1111
p.P103S	DO229224	THCA	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	0.1667
p.P111Q	DO229240	THCA	ICGC	PRPSLAKLS	DEG_APCC_DBOX_1	0.5924
p.P111L	SIDM01117	Small Cell Lung Carcinoma	GDSC	PRPSLAKLS	DEG_APCC_DBOX_1	0.6471
p.S105N	SIDM00120	Prostate Carcinoma	GDSC	PRPSLAKLS	DEG_APCC_DBOX_1	0.2222
p.S105N	ACH-000979	Prostate Cancer	CCLE	PRPSLAKLS	DEG_APCC_DBOX_1	0.2222
p.S105N	DU-145	prostate	COSMIC	PRPSLAKLS	DEG_APCC_DBOX_1	0.2222
p.P123Q	SIDM00656	Burkitt's Lymphoma	GDSC	PRPSLAKLS	DEG_APCC_DBOX_1	0.1667
p.P123Q	ACH-000944	Lymphoma	CCLE	PRPSLAKLS	DEG_APCC_DBOX_1	0.1667
p.P123Q	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	PRPSLAKLS	DEG_APCC_DBOX_1	0.1667
p.R100Q	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	PRPSLAKLS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDG6	ATP-dependent RNA helicase TDRD9	DEG_APCC_DBOX_1	109:117	PRPSLAKLS	APC,CDC20,FZR1	0.7231	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons