DegronMD - Q8NDT2(RBM15B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R521S	TCGA-09-2044	OV	TCGA	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556
p.R521S	DO28923	OV	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556
p.Q502E	TCGA-23-2645	OV	TCGA	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.2222
p.Q502E	DO30890	OV	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.2222
p.R519W	TCGA-2W-A8YY	CESC	TCGA	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1111
p.R519W	DO223732	CESC	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1111
p.R519W	SIDM01085	Bladder Carcinoma	GDSC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1111
p.R519W	ACH-000242	Bladder Cancer	CCLE	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1111
p.R519W	RT4	urinary tract	COSMIC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1111
p.S504L	TCGA-AX-A0J0	UCEC	TCGA	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation blocking phosphorylation signal	0.7222
p.S504L	DO41133	UCEC	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation blocking phosphorylation signal	0.7222
p.P503L	TCGA-BF-AAP2	SKCM	TCGA	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.25
p.P503L	DO219466	SKCM	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.25
p.P498S	TCGA-EE-A2A5	SKCM	TCGA	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1111
p.P498S	DO37941	SKCM	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1111
p.D515N	TCGA-EE-A3J5	SKCM	TCGA	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.2222
p.D515N	DO47331	SKCM	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.2222
p.R496W	TCGA-EY-A1GI	UCEC	TCGA	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556
p.R496W	DO41211	UCEC	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556
p.H509D	TCGA-KU-A66S	HNSC	TCGA	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation altering degron motif	0.7688
p.H509D	DO44456	HNSC	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation altering degron motif	0.7688
p.R519G	TCGA-Y8-A8RZ	KIRP	TCGA	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1111
p.R519G	DO49807	KIRP	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1111
p.R521H	DO233764	GACA	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556
p.R521H	SIDM00217	Colorectal Carcinoma	GDSC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556
p.R521H	ACH-000999	Colon/Colorectal Cancer	CCLE	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556
p.R521H	SNU-1040	large intestine	COSMIC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556
p.Y517C	DO35442	PACA	ICGC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation blocking phosphorylation signal	0.6111
p.G516E	SIDM00190	Melanoma	GDSC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1944
p.G516E	ACH-002097	Skin Cancer	CCLE	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1944
p.G516E	CP66-MEL	skin	COSMIC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1944
p.Q500R	SIDM00487	Colorectal Carcinoma	GDSC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1667
p.Q500R	ACH-000963	Colon/Colorectal Cancer	CCLE	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1667
p.Q500R	CCK-81	large intestine	COSMIC	LPVHYE	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1667

Kaplan plot for RBM15B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM15B

UniProt ID: Q8NDT2

Entrez ID: 29890

Protein name: Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM15B in