DegronMD

Uniprot ID: Q8NDT2

Source protein: Putative RNA-binding protein 15B

Source gene: RBM15B

Class: LIG_APCC_ABBA_1

Location: 506:511

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9917

ASA_SCORE: 61.7

COIL: 0.697

CONS_SCORE: 0.2569

DSS_SCORE: 0.4931

HELIX: 0.1333

FCONS_SCORE: 0.8749

RIG_SCORE: 0.765

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R521S	TCGA-09-2044	OV	TCGA	LPVHYE	LIG_APCC_ABBA_1	0.0556
p.R521S	DO28923	OV	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.0556
p.Q502E	TCGA-23-2645	OV	TCGA	LPVHYE	LIG_APCC_ABBA_1	0.2222
p.Q502E	DO30890	OV	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.2222
p.R519W	TCGA-2W-A8YY	CESC	TCGA	LPVHYE	LIG_APCC_ABBA_1	0.1111
p.R519W	DO223732	CESC	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.1111
p.R519W	SIDM01085	Bladder Carcinoma	GDSC	LPVHYE	LIG_APCC_ABBA_1	0.1111
p.R519W	ACH-000242	Bladder Cancer	CCLE	LPVHYE	LIG_APCC_ABBA_1	0.1111
p.R519W	RT4	urinary_tract	COSMIC	LPVHYE	LIG_APCC_ABBA_1	0.1111
p.S504L	TCGA-AX-A0J0	UCEC	TCGA	LPVHYE	LIG_APCC_ABBA_1	0.7222
p.S504L	DO41133	UCEC	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.7222
p.P503L	TCGA-BF-AAP2	SKCM	TCGA	LPVHYE	LIG_APCC_ABBA_1	0.25
p.P503L	DO219466	SKCM	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.25
p.P498S	TCGA-EE-A2A5	SKCM	TCGA	LPVHYE	LIG_APCC_ABBA_1	0.1111
p.P498S	DO37941	SKCM	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.1111
p.D515N	TCGA-EE-A3J5	SKCM	TCGA	LPVHYE	LIG_APCC_ABBA_1	0.2222
p.D515N	DO47331	SKCM	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.2222
p.R496W	TCGA-EY-A1GI	UCEC	TCGA	LPVHYE	LIG_APCC_ABBA_1	0.0556
p.R496W	DO41211	UCEC	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.0556
p.H509D	TCGA-KU-A66S	HNSC	TCGA	LPVHYE	LIG_APCC_ABBA_1	0.7688
p.H509D	DO44456	HNSC	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.7688
p.R519G	TCGA-Y8-A8RZ	KIRP	TCGA	LPVHYE	LIG_APCC_ABBA_1	0.1111
p.R519G	DO49807	KIRP	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.1111
p.R521H	DO233764	GACA	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.0556
p.R521H	SIDM00217	Colorectal Carcinoma	GDSC	LPVHYE	LIG_APCC_ABBA_1	0.0556
p.R521H	ACH-000999	Colon/Colorectal Cancer	CCLE	LPVHYE	LIG_APCC_ABBA_1	0.0556
p.R521H	SNU-1040	large_intestine	COSMIC	LPVHYE	LIG_APCC_ABBA_1	0.0556
p.Y517C	DO35442	PACA	ICGC	LPVHYE	LIG_APCC_ABBA_1	0.6111
p.G516E	SIDM00190	Melanoma	GDSC	LPVHYE	LIG_APCC_ABBA_1	0.1944
p.G516E	ACH-002097	Skin Cancer	CCLE	LPVHYE	LIG_APCC_ABBA_1	0.1944
p.G516E	CP66-MEL	skin	COSMIC	LPVHYE	LIG_APCC_ABBA_1	0.1944
p.Q500R	SIDM00487	Colorectal Carcinoma	GDSC	LPVHYE	LIG_APCC_ABBA_1	0.1667
p.Q500R	ACH-000963	Colon/Colorectal Cancer	CCLE	LPVHYE	LIG_APCC_ABBA_1	0.1667
p.Q500R	CCK-81	large_intestine	COSMIC	LPVHYE	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPVHYE

Degron related mutations and impact score

Drug responses associated with RBM15B mutations

All proteins holding degron of LPVHYE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDT2	Putative RNA-binding protein 15B	LIG_APCC_ABBA_1	506:511	LPVHYE	APC,CDC20,FZR1	0.9917	More...