DegronMD - Q8NE09(RGS22)

FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. {ECO:0000250}.

GO - Biological processes (BP): negative regulation of signal transduction [GO:0009968]

GO - Molecular function (MF): G-protein alpha-subunit binding [GO:0001965]

GO - Cellular component (CC): actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V638M	ACH-000953	Leukemia	CCLE	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.7208
p.V638M	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.7208
p.E637K	JSC-1	haematopoietic and lymphoid tissue	COSMIC	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.7022
p.A640D	DO229037	LICA	ICGC	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.6682
p.E644A	TCGA-EO-A22R	UCEC	TCGA	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.659
p.E644A	DO42713	UCEC	ICGC	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.659
p.Y639H	TCGA-B5-A1MR	UCEC	TCGA	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.6118
p.Y639H	DO41758	UCEC	ICGC	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.6118
p.A640T	TCGA-AA-3544	COAD	TCGA	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.6028
p.A640T	TCGA-CG-5733	STAD	TCGA	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.6028
p.A640T	TCGA-D1-A1NY	UCEC	TCGA	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.6028
p.A640T	DO9130	COAD	ICGC	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.6028
p.A640T	DO38551	STAD	ICGC	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.6028
p.A640T	DO42512	UCEC	ICGC	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.6028
p.E644K	TCGA-F5-6814	READ	TCGA	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.591
p.E644K	DO36556	READ	ICGC	DRRYAYTEEP	CBL_PTK	636:645	Mutation altering degron motif	0.591
p.K632Q	H2804	pleura	COSMIC	DRRYAYTEEP	CBL_PTK	636:645	Mutation substituting flanking lysine	0.3333
p.G646D	CTV-1	haematopoietic and lymphoid tissue	COSMIC	DRRYAYTEEP	CBL_PTK	636:645	Mutation rewiring degron network	0.3056
p.P633T	DO229029	LICA	ICGC	DRRYAYTEEP	CBL_PTK	636:645	Mutation rewiring degron network	0.25
p.T649I	TCGA-EE-A3JD	SKCM	TCGA	DRRYAYTEEP	CBL_PTK	636:645	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 27 entries

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Kaplan plot for RGS22 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGS22

UniProt ID: Q8NE09

Entrez ID: 26166

Protein name: Regulator of G-protein signaling 22 (RGS22)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGS22 in