DegronMD

Uniprot ID: Q8NE09

Source protein: Regulator of G-protein signaling 22

Source gene: RGS22

Class: CBL_PTK

Location: 636:645

E3 ligase: CBL

DEGRON score: 0.505

ASA_SCORE: 105.4

COIL: 0.7745

CONS_SCORE: 0.1966

DSS_SCORE: 0.3699

HELIX: 0.1345

FCONS_SCORE: 0.7033

RIG_SCORE: 0.8072

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A640T	TCGA-AA-3544	COAD	TCGA	DRRYAYTEEP	CBL_PTK	0.6028
p.A640T	TCGA-CG-5733	STAD	TCGA	DRRYAYTEEP	CBL_PTK	0.6028
p.A640T	TCGA-D1-A1NY	UCEC	TCGA	DRRYAYTEEP	CBL_PTK	0.6028
p.A640T	DO9130	COAD	ICGC	DRRYAYTEEP	CBL_PTK	0.6028
p.A640T	DO38551	STAD	ICGC	DRRYAYTEEP	CBL_PTK	0.6028
p.A640T	DO42512	UCEC	ICGC	DRRYAYTEEP	CBL_PTK	0.6028
p.Y639H	TCGA-B5-A1MR	UCEC	TCGA	DRRYAYTEEP	CBL_PTK	0.6118
p.Y639H	DO41758	UCEC	ICGC	DRRYAYTEEP	CBL_PTK	0.6118
p.T649I	TCGA-EE-A3JD	SKCM	TCGA	DRRYAYTEEP	CBL_PTK	0.2222
p.T649I	DO50299	SKCM	ICGC	DRRYAYTEEP	CBL_PTK	0.2222
p.E644A	TCGA-EO-A22R	UCEC	TCGA	DRRYAYTEEP	CBL_PTK	0.659
p.E644A	DO42713	UCEC	ICGC	DRRYAYTEEP	CBL_PTK	0.659
p.E644K	TCGA-F5-6814	READ	TCGA	DRRYAYTEEP	CBL_PTK	0.591
p.E644K	DO36556	READ	ICGC	DRRYAYTEEP	CBL_PTK	0.591
p.T649N	TCGA-HZ-7289	PAAD	TCGA	DRRYAYTEEP	CBL_PTK	0.2222
p.T649N	DO32793	PAAD	ICGC	DRRYAYTEEP	CBL_PTK	0.2222
p.P633T	DO229029	LICA	ICGC	DRRYAYTEEP	CBL_PTK	0.25
p.A640D	DO229037	LICA	ICGC	DRRYAYTEEP	CBL_PTK	0.6682
p.V653D	DO46400	OV	ICGC	DRRYAYTEEP	CBL_PTK	0.1111
p.V650M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	DRRYAYTEEP	CBL_PTK	0.1944
p.V650M	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DRRYAYTEEP	CBL_PTK	0.1944
p.V638M	ACH-000953	Leukemia	CCLE	DRRYAYTEEP	CBL_PTK	0.7208
p.V638M	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DRRYAYTEEP	CBL_PTK	0.7208
p.G646D	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	DRRYAYTEEP	CBL_PTK	0.3056
p.E637K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	DRRYAYTEEP	CBL_PTK	0.7022
p.N652S	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	DRRYAYTEEP	CBL_PTK	0.1389
p.K632Q	H2804	pleura	COSMIC	DRRYAYTEEP	CBL_PTK	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NE09	Regulator of G-protein signaling 22	CBL_PTK	636:645	DRRYAYTEEP	CBL	0.505	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRRYAYTEEP

Degron related mutations and impact score

Drug responses associated with RGS22 mutations

All proteins holding degron of DRRYAYTEEP