DegronMD - Q8NEC7(GSTCD)

GO - Biological processes (BP):

GO - Molecular function (MF):

GO - Cellular component (CC): cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
VRVHND	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Glutathione S-transferase C-terminal domain-containing protein	187:192	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D192H	SIDM00875	Breast Carcinoma	GDSC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation altering degron motif	0.7688
p.D192H	ACH-000624	Breast Cancer	CCLE	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation altering degron motif	0.7688
p.D192H	HCC1806	breast	COSMIC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation altering degron motif	0.7688
p.S184I	ACH-002038	Ovarian Cancer	CCLE	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation blocking phosphorylation signal	0.6944
p.V187A	DO222798	COCA	ICGC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation altering degron motif	0.6936
p.N191T	TCGA-AN-A046	BRCA	TCGA	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation altering degron motif	0.5944
p.N191T	DO1285	BRCA	ICGC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation altering degron motif	0.5944
p.P186S	DO230326	COCA	ICGC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.3056
p.E185K	TCGA-DU-6392	LGG	TCGA	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.2778
p.E185K	TCGA-EK-A3GM	CESC	TCGA	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.2778
p.E185K	DO49966	CESC	ICGC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.2778
p.E185K	DO22237	LGG	ICGC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.2778
p.K199R	TCGA-B5-A1MX	UCEC	TCGA	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation substituting flanking lysine	0.25
p.K199R	DO41999	UCEC	ICGC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation substituting flanking lysine	0.25
p.A199T	23132-87	stomach	COSMIC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation substituting flanking lysine	0.25
p.L183R	TCGA-A5-A2K5	UCEC	TCGA	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.2222
p.L183R	DO41379	UCEC	ICGC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.2222
p.R196C	TCGA-AJ-A3BG	UCEC	TCGA	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.2222
p.R196C	DO42633	UCEC	ICGC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.2222
p.R196H	SIDM00554	Ovarian Carcinoma	GDSC	VRVHND	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 26 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GSTCD

UniProt ID: Q8NEC7

Entrez ID: 79807

Protein name: Glutathione S-transferase C-terminal domain-containing protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GSTCD in