DegronMD

Uniprot ID: Q8NEC7

Source protein: Glutathione S-transferase C-terminal domain-containing protein

Source gene: GSTCD

Class: LIG_APCC_ABBA_1

Location: 187:192

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9964

ASA_SCORE: 86.1

COIL: 0.7342

CONS_SCORE: 0.4756

DSS_SCORE: 0.5605

HELIX: 0.2027

FCONS_SCORE: 1.1126

RIG_SCORE: 0.7383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L183R	TCGA-A5-A2K5	UCEC	TCGA	VRVHND	LIG_APCC_ABBA_1	0.2222
p.L183R	DO41379	UCEC	ICGC	VRVHND	LIG_APCC_ABBA_1	0.2222
p.R196C	TCGA-AJ-A3BG	UCEC	TCGA	VRVHND	LIG_APCC_ABBA_1	0.2222
p.R196C	DO42633	UCEC	ICGC	VRVHND	LIG_APCC_ABBA_1	0.2222
p.N191T	TCGA-AN-A046	BRCA	TCGA	VRVHND	LIG_APCC_ABBA_1	0.5944
p.N191T	DO1285	BRCA	ICGC	VRVHND	LIG_APCC_ABBA_1	0.5944
p.E180D	TCGA-AX-A05Z	UCEC	TCGA	VRVHND	LIG_APCC_ABBA_1	0.1389
p.E180D	DO40884	UCEC	ICGC	VRVHND	LIG_APCC_ABBA_1	0.1389
p.K199R	TCGA-B5-A1MX	UCEC	TCGA	VRVHND	LIG_APCC_ABBA_1	0.25
p.K199R	DO41999	UCEC	ICGC	VRVHND	LIG_APCC_ABBA_1	0.25
p.E185K	TCGA-DU-6392	LGG	TCGA	VRVHND	LIG_APCC_ABBA_1	0.2778
p.E185K	TCGA-EK-A3GM	CESC	TCGA	VRVHND	LIG_APCC_ABBA_1	0.2778
p.E185K	DO49966	CESC	ICGC	VRVHND	LIG_APCC_ABBA_1	0.2778
p.E185K	DO22237	LGG	ICGC	VRVHND	LIG_APCC_ABBA_1	0.2778
p.P186S	DO230326	COCA	ICGC	VRVHND	LIG_APCC_ABBA_1	0.3056
p.V187A	DO222798	COCA	ICGC	VRVHND	LIG_APCC_ABBA_1	0.6936
p.D192H	SIDM00875	Breast Carcinoma	GDSC	VRVHND	LIG_APCC_ABBA_1	0.7688
p.D192H	ACH-000624	Breast Cancer	CCLE	VRVHND	LIG_APCC_ABBA_1	0.7688
p.D192H	HCC1806	breast	COSMIC	VRVHND	LIG_APCC_ABBA_1	0.7688
p.R196H	SIDM00554	Ovarian Carcinoma	GDSC	VRVHND	LIG_APCC_ABBA_1	0.2222
p.R196H	ACH-000524	Ovarian Cancer	CCLE	VRVHND	LIG_APCC_ABBA_1	0.2222
p.R196H	KURAMOCHI	ovary	COSMIC	VRVHND	LIG_APCC_ABBA_1	0.2222
p.R196S	SIDM00991	T-Lymphoblastic Leukemia	GDSC	VRVHND	LIG_APCC_ABBA_1	0.2222
p.R196S	ACH-000519	Leukemia	CCLE	VRVHND	LIG_APCC_ABBA_1	0.2222
p.S184I	ACH-002038	Ovarian Cancer	CCLE	VRVHND	LIG_APCC_ABBA_1	0.6944
p.A199T	23132-87	stomach	COSMIC	VRVHND	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEC7	Glutathione S-transferase C-terminal domain-containing protein	LIG_APCC_ABBA_1	187:192	VRVHND	APC,CDC20,FZR1	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons