DegronMD - Q8NEG2(C7orf57)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L263I	TCGA-32-4211	GBM	TCGA	PEDTPESS	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.0833
p.V286I	TCGA-A5-A0G1	UCEC	TCGA	PEDTPESS	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1389
p.E273K	TCGA-BI-A20A	CESC	TCGA	PEDTPESS	DEG_SCF_FBW7_1	272:279	Mutation altering degron motif	0.591
p.S281N	TCGA-BS-A0UM	UCEC	TCGA	PEDTPESS	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.2778
p.N279S	DO7801	COAD	ICGC	PEDTPESS	DEG_SCF_FBW7_1	272:279	Mutation altering degron motif	0.7069
p.P286H	DO8296	COAD	ICGC	PEDTPESS	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1389
p.R272M	DO37405	SKCM	ICGC	PEDTPESS	DEG_SCF_FBW7_1	272:279	Mutation altering degron motif	0.8632
p.E284K	DO47625	SKCM	ICGC	PEDTPESS	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1944
p.P280Q	DO38165	SKCM	ICGC	PEDTPESS	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.3056
p.A266T	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PEDTPESS	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons