DegronMD

Uniprot ID: Q8NEG2

Source protein: Uncharacterized protein C7orf57

Source gene: C7orf57

Class: DEG_SCF_FBW7_1

Location: 272:279

E3 ligase: FBXW7

DEGRON score: 0.9793

ASA_SCORE: 95.775

COIL: 0.9194

CONS_SCORE: 0.3646

DSS_SCORE: 0.9271

HELIX: 0.059

FCONS_SCORE: 1.1916

RIG_SCORE: 0.5158

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L263I	TCGA-32-4211	GBM	TCGA	PEDTPESS	DEG_SCF_FBW7_1	0.0833
p.V286I	TCGA-A5-A0G1	UCEC	TCGA	PEDTPESS	DEG_SCF_FBW7_1	0.1389
p.E273K	TCGA-BI-A20A	CESC	TCGA	PEDTPESS	DEG_SCF_FBW7_1	0.591
p.S281N	TCGA-BS-A0UM	UCEC	TCGA	PEDTPESS	DEG_SCF_FBW7_1	0.2778
p.N279S	DO7801	COAD	ICGC	PEDTPESS	DEG_SCF_FBW7_1	0.7069
p.P286H	DO8296	COAD	ICGC	PEDTPESS	DEG_SCF_FBW7_1	0.1389
p.R272M	DO37405	SKCM	ICGC	PEDTPESS	DEG_SCF_FBW7_1	0.8632
p.E284K	DO47625	SKCM	ICGC	PEDTPESS	DEG_SCF_FBW7_1	0.1944
p.P280Q	DO38165	SKCM	ICGC	PEDTPESS	DEG_SCF_FBW7_1	0.3056
p.A266T	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PEDTPESS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEG2	Uncharacterized protein C7orf57	DEG_SCF_FBW7_1	272:279	PEDTPESS	FBXW7	0.9793	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons