DegronMD - Q8NEG7(DENND6B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q425H	TCGA-06-5416	GBM	TCGA	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.3056
p.Q425H	DO10880	GBM	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.3056
p.Q425H	DO230942	LUSC	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.3056
p.Q425H	DO224589	LUSC	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.3056
p.R418L	TCGA-97-7937	LUAD	TCGA	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.7316
p.R418L	DO25649	LUAD	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.7316
p.R418W	TCGA-FY-A3NM	THCA	TCGA	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.7523
p.R418W	DO38954	THCA	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.7523
p.R418W	SIDM00167	Head and Neck Carcinoma	GDSC	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.7523
p.R407W	TCGA-IB-7651	PAAD	TCGA	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.0833
p.R407W	DO46657	PAAD	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.0833
p.R407W	DO229268	THCA	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.0833
p.D410Y	DO229232	THCA	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.1667
p.L421P	DO229232	THCA	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.6471
p.I428V	SIDM00957	Colorectal Carcinoma	GDSC	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.2222
p.I428V	ACH-000350	Colon/Colorectal Cancer	CCLE	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.2222
p.E422K	ACH-000960	Leukemia	CCLE	LRRHLLELT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.591

Kaplan plot for DENND6B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DENND6B

UniProt ID: Q8NEG7

Entrez ID: 414918

Protein name: Protein DENND6B (DENN domain-containing protein 6B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DENND6B in