DegronMD

Uniprot ID: Q8NEG7

Source protein: Protein DENND6B

Source gene: DENND6B

Class: DEG_APCC_DBOX_1

Location: 416:424

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5756

ASA_SCORE: 41.9

COIL: 0.0083

CONS_SCORE: 0.6674

DSS_SCORE: 0.0958

HELIX: 0.9909

FCONS_SCORE: 1.3154

RIG_SCORE: 0.8483

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q425H	TCGA-06-5416	GBM	TCGA	LRRHLLELT	DEG_APCC_DBOX_1	0.3056
p.Q425H	DO10880	GBM	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	0.3056
p.Q425H	DO230942	LUSC	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	0.3056
p.Q425H	DO224589	LUSC	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	0.3056
p.R418L	TCGA-97-7937	LUAD	TCGA	LRRHLLELT	DEG_APCC_DBOX_1	0.7316
p.R418L	DO25649	LUAD	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	0.7316
p.R418W	TCGA-FY-A3NM	THCA	TCGA	LRRHLLELT	DEG_APCC_DBOX_1	0.7523
p.R418W	DO38954	THCA	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	0.7523
p.R418W	SIDM00167	Head and Neck Carcinoma	GDSC	LRRHLLELT	DEG_APCC_DBOX_1	0.7523
p.R407W	TCGA-IB-7651	PAAD	TCGA	LRRHLLELT	DEG_APCC_DBOX_1	0.0833
p.R407W	DO46657	PAAD	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	0.0833
p.R407W	DO229268	THCA	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	0.0833
p.D410Y	DO229232	THCA	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	0.1667
p.L421P	DO229232	THCA	ICGC	LRRHLLELT	DEG_APCC_DBOX_1	0.6471
p.I428V	SIDM00957	Colorectal Carcinoma	GDSC	LRRHLLELT	DEG_APCC_DBOX_1	0.2222
p.I428V	ACH-000350	Colon/Colorectal Cancer	CCLE	LRRHLLELT	DEG_APCC_DBOX_1	0.2222
p.E422K	ACH-000960	Leukemia	CCLE	LRRHLLELT	DEG_APCC_DBOX_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEG7	Protein DENND6B	DEG_APCC_DBOX_1	416:424	LRRHLLELT	APC,CDC20,FZR1	0.5756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons