DegronMD - Q8NEH6(MNS1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D315Y	TCGA-06-5416	GBM	TCGA	RQELYQE	LIG_APCC_ABBAyCdc20_2	320:326	Mutation rewiring degron network	0.1944
p.D315Y	DO10880	GBM	ICGC	RQELYQE	LIG_APCC_ABBAyCdc20_2	320:326	Mutation rewiring degron network	0.1944
p.Q325K	TCGA-09-2044	OV	TCGA	RQELYQE	LIG_APCC_ABBAyCdc20_2	320:326	Mutation altering degron motif	0.5833
p.Q325K	DO28923	OV	ICGC	RQELYQE	LIG_APCC_ABBAyCdc20_2	320:326	Mutation altering degron motif	0.5833
p.E314G	TCGA-DI-A1BU	UCEC	TCGA	RQELYQE	LIG_APCC_ABBAyCdc20_2	320:326	Mutation rewiring degron network	0.1667
p.E314G	DO42023	UCEC	ICGC	RQELYQE	LIG_APCC_ABBAyCdc20_2	320:326	Mutation rewiring degron network	0.1667
p.R311Q	TCGA-L5-A4OI	ESCA	TCGA	RQELYQE	LIG_APCC_ABBAyCdc20_2	320:326	Mutation rewiring degron network	0.0833
p.Q321K	DO228978	LICA	ICGC	RQELYQE	LIG_APCC_ABBAyCdc20_2	320:326	Mutation altering degron motif	0.5833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons