DegronMD

Uniprot ID: Q8NEH6

Source protein: Meiosis-specific nuclear structural protein 1

Source gene: MNS1

Class: LIG_APCC_ABBAyCdc20_2

Location: 320:326

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8109

ASA_SCORE: 105.0429

COIL: 0.0483

CONS_SCORE: 0.6722

DSS_SCORE: 0.3338

HELIX: 0.9501

FCONS_SCORE: 1.2349

RIG_SCORE: 0.779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D315Y	TCGA-06-5416	GBM	TCGA	RQELYQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D315Y	DO10880	GBM	ICGC	RQELYQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q325K	TCGA-09-2044	OV	TCGA	RQELYQE	LIG_APCC_ABBAyCdc20_2	0.5833
p.Q325K	DO28923	OV	ICGC	RQELYQE	LIG_APCC_ABBAyCdc20_2	0.5833
p.E314G	TCGA-DI-A1BU	UCEC	TCGA	RQELYQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E314G	DO42023	UCEC	ICGC	RQELYQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R311Q	TCGA-L5-A4OI	ESCA	TCGA	RQELYQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q321K	DO228978	LICA	ICGC	RQELYQE	LIG_APCC_ABBAyCdc20_2	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEH6	Meiosis-specific nuclear structural protein 1	LIG_APCC_ABBAyCdc20_2	320:326	RQELYQE	APC,CDC20,FZR1	0.8109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons