DegronMD - Q8NEN9(PDZD8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S980G	TCGA-17-Z059	LUAD	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation blocking phosphorylation signal	0.6389
p.D962Y	TCGA-63-A5MB	LUSC	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation rewiring degron network	0.1667
p.D962Y	DO52018	LUSC	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation rewiring degron network	0.1667
p.P972H	TCGA-AA-3492	COAD	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation altering degron motif	0.7694
p.P972H	DO8224	COAD	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation altering degron motif	0.7694
p.T974M	TCGA-B5-A3FC	UCEC	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation altering degron motif	0.7423
p.T974M	TCGA-DU-6392	LGG	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation altering degron motif	0.7423
p.T974M	DO22237	LGG	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation altering degron motif	0.7423
p.T974M	DO41871	UCEC	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation altering degron motif	0.7423
p.T982M	TCGA-CQ-6218	HNSC	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation rewiring degron network	0.1389
p.T982M	DO14180	HNSC	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation rewiring degron network	0.1389
p.D976V	TCGA-DF-A2KN	UCEC	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation rewiring degron network	0.3056
p.D976V	DO223282	UCEC	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation rewiring degron network	0.3056
p.N977K	DO229018	LICA	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation rewiring degron network	0.2778
p.P966T	DO229031	LICA	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	968:975	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons