DegronMD

Uniprot ID: Q8NEN9

Source protein: PDZ domain-containing protein 8

Source gene: PDZD8

Class: DEG_SCF_FBW7_1

Location: 968:975

E3 ligase: FBXW7

DEGRON score: 0.9576

ASA_SCORE: 92.2

COIL: 0.9216

CONS_SCORE: 0.3885

DSS_SCORE: 0.7634

HELIX: 0.0341

FCONS_SCORE: 1.0849

RIG_SCORE: 0.5541

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S980G	TCGA-17-Z059	LUAD	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	0.6389
p.D962Y	TCGA-63-A5MB	LUSC	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	0.1667
p.D962Y	DO52018	LUSC	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	0.1667
p.P972H	TCGA-AA-3492	COAD	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	0.7694
p.P972H	DO8224	COAD	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	0.7694
p.T974M	TCGA-B5-A3FC	UCEC	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	0.7423
p.T974M	TCGA-DU-6392	LGG	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	0.7423
p.T974M	DO22237	LGG	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	0.7423
p.T974M	DO41871	UCEC	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	0.7423
p.T982M	TCGA-CQ-6218	HNSC	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	0.1389
p.T982M	DO14180	HNSC	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	0.1389
p.D976V	TCGA-DF-A2KN	UCEC	TCGA	PKHTPNTS	DEG_SCF_FBW7_1	0.3056
p.D976V	DO223282	UCEC	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	0.3056
p.N977K	DO229018	LICA	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	0.2778
p.P966T	DO229031	LICA	ICGC	PKHTPNTS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEN9	PDZ domain-containing protein 8	DEG_SCF_FBW7_1	968:975	PKHTPNTS	FBXW7	0.9576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons