DegronMD - Q8NES3(LFNG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R29M	TCGA-3Z-A93Z	KIRC	TCGA	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0833
p.R29M	DO219229	KIRC	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0833
p.E33K	TCGA-66-2773	LUSC	TCGA	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1944
p.E33K	DO26536	LUSC	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1944
p.R44I	TCGA-AJ-A3EL	UCEC	TCGA	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.8102
p.R44I	DO233293	NACA	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.8102
p.R44I	DO41542	UCEC	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.8102
p.D55G	DO52478	COCA	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0833
p.T42M	DO228967	LICA	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7423
p.P48S	DO220851	MELA	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.2778
p.M35R	DO46420	OV	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.25
p.G28R	SIDM00353	Other Sarcomas	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0556
p.G28R	SIDM01526	Mesothelioma	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0556
p.G28R	SIDM00163	Biliary Tract Carcinoma	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0556
p.D43N	SIDM00189	Melanoma	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.6932
p.D43N	ACH-002098	Skin Cancer	CCLE	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.6932
p.T46I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7078
p.T46I	SIDM00277	Acute Myeloid Leukemia	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7078
p.T46I	SIDM01706	Hodgkin's Lymphoma	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7078
p.E39K	SIDM01082	Oral Cavity Carcinoma	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7022
p.E39K	ACH-000188	Head and Neck Cancer	CCLE	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7022
p.G52A	ACH-002040	Skin Cancer	CCLE	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1667
p.Q46R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7329
p.Q44R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	GRRALRSLA	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7329

Kaplan plot for LFNG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LFNG

UniProt ID: Q8NES3

Entrez ID: 3955

Protein name: Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LFNG in