DegronMD

Uniprot ID: Q8NES3

Source protein: Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

Source gene: LFNG

Class: DEG_APCC_DBOX_1

Location: 38:46

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6214

ASA_SCORE: 87.7222

COIL: 0.5974

CONS_SCORE: 0.3474

DSS_SCORE: 0.5292

HELIX: 0.3322

FCONS_SCORE: 1.2337

RIG_SCORE: 0.6991

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R29M	TCGA-3Z-A93Z	KIRC	TCGA	GRRALRSLA	DEG_APCC_DBOX_1	0.0833
p.R29M	DO219229	KIRC	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	0.0833
p.E33K	TCGA-66-2773	LUSC	TCGA	GRRALRSLA	DEG_APCC_DBOX_1	0.1944
p.E33K	DO26536	LUSC	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	0.1944
p.R44I	TCGA-AJ-A3EL	UCEC	TCGA	GRRALRSLA	DEG_APCC_DBOX_1	0.8102
p.R44I	DO233293	NACA	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	0.8102
p.R44I	DO41542	UCEC	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	0.8102
p.D55G	DO52478	COCA	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	0.0833
p.T42M	DO228967	LICA	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	0.7423
p.P48S	DO220851	MELA	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	0.2778
p.M35R	DO46420	OV	ICGC	GRRALRSLA	DEG_APCC_DBOX_1	0.25
p.G28R	SIDM00353	Other Sarcomas	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	0.0556
p.G28R	SIDM01526	Mesothelioma	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	0.0556
p.G28R	SIDM00163	Biliary Tract Carcinoma	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	0.0556
p.D43N	SIDM00189	Melanoma	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	0.6932
p.D43N	ACH-002098	Skin Cancer	CCLE	GRRALRSLA	DEG_APCC_DBOX_1	0.6932
p.T46I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	0.7078
p.T46I	SIDM00277	Acute Myeloid Leukemia	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	0.7078
p.T46I	SIDM01706	Hodgkin's Lymphoma	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	0.7078
p.E39K	SIDM01082	Oral Cavity Carcinoma	GDSC	GRRALRSLA	DEG_APCC_DBOX_1	0.7022
p.E39K	ACH-000188	Head and Neck Cancer	CCLE	GRRALRSLA	DEG_APCC_DBOX_1	0.7022
p.G52A	ACH-002040	Skin Cancer	CCLE	GRRALRSLA	DEG_APCC_DBOX_1	0.1667
p.Q46R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	GRRALRSLA	DEG_APCC_DBOX_1	0.7329
p.Q44R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	GRRALRSLA	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NES3	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe	DEG_APCC_DBOX_1	38:46	GRRALRSLA	APC,CDC20,FZR1	0.6214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRRALRSLA

Degron related mutations and impact score

Drug responses associated with LFNG mutations

All proteins holding degron of GRRALRSLA