DegronMD - Q8NF64(ZMIZ2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S382G	TCGA-24-2035	OV	TCGA	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation blocking phosphorylation signal	0.6944
p.S381I	TCGA-34-A5IX	LUSC	TCGA	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation blocking phosphorylation signal	0.7222
p.S383N	TCGA-G2-AA3F	BLCA	TCGA	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation rewiring degron network	0.2222
p.T379S	TCGA-OR-A5JP	ACC	TCGA	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation altering degron motif	0.6005
p.H383Q	DO7776	COAD	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation rewiring degron network	0.2222
p.L382F	DO229010	COCA	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation blocking phosphorylation signal	0.6944
p.L382F	DO229013	COCA	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation blocking phosphorylation signal	0.6944
p.L382F	DO229353	LAML	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation blocking phosphorylation signal	0.6944
p.L382F	DO229480	LAML	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation blocking phosphorylation signal	0.6944
p.L382F	DO231140	LAML	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation blocking phosphorylation signal	0.6944
p.L382F	DO230993	LUSC	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation blocking phosphorylation signal	0.6944
p.R364Q	DO233942	GACA	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation rewiring degron network	0.0556
p.E366K	DO11100	GBM	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation rewiring degron network	0.1111
p.D374N	DO22295	LGG	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation altering degron motif	0.6932
p.L372F	DO229045	LICA	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation rewiring degron network	0.2778
p.L382V	DO220854	MELA	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation blocking phosphorylation signal	0.6944
p.H382Y	DO232224	PBCA	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation blocking phosphorylation signal	0.6944
p.R379C	DO38567	STAD	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation altering degron motif	0.8301
p.Q365R	DO38727	STAD	ICGC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation blocking phosphorylation signal	0.5278
p.V373A	KON	upper aerodigestive tract	COSMIC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation rewiring degron network	0.3056
p.R370C	SNU-1040	large intestine	COSMIC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation rewiring degron network	0.2222
p.T366I	SLVL	haematopoietic and lymphoid tissue	COSMIC	PTPPMT	DEG_SCF_FBW7_1	374:379	Mutation rewiring degron network	0.1111

Kaplan plot for ZMIZ2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZMIZ2

UniProt ID: Q8NF64

Entrez ID: 83637

Protein name: Zinc finger MIZ domain-containing protein 2 (PIAS-like protein Zimp7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZMIZ2 in