DegronMD

Uniprot ID: Q8NF64

Source protein: Zinc finger MIZ domain-containing protein 2

Source gene: ZMIZ2

Class: DEG_SCF_FBW7_1

Location: 374:379

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 81.3833

COIL: 0.9472

CONS_SCORE: 0.3974

DSS_SCORE: 0.6505

HELIX: 0.0152

FCONS_SCORE: 1.0686

RIG_SCORE: 0.5172

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S382G	TCGA-24-2035	OV	TCGA	PTPPMT	DEG_SCF_FBW7_1	0.6944
p.S381I	TCGA-34-A5IX	LUSC	TCGA	PTPPMT	DEG_SCF_FBW7_1	0.7222
p.S383N	TCGA-G2-AA3F	BLCA	TCGA	PTPPMT	DEG_SCF_FBW7_1	0.2222
p.T379S	TCGA-OR-A5JP	ACC	TCGA	PTPPMT	DEG_SCF_FBW7_1	0.6005
p.H383Q	DO7776	COAD	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.2222
p.L382F	DO229010	COCA	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.6944
p.L382F	DO229013	COCA	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.6944
p.L382F	DO229353	LAML	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.6944
p.L382F	DO229480	LAML	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.6944
p.L382F	DO231140	LAML	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.6944
p.L382F	DO230993	LUSC	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.6944
p.R364Q	DO233942	GACA	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.0556
p.E366K	DO11100	GBM	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.1111
p.D374N	DO22295	LGG	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.6932
p.L372F	DO229045	LICA	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.2778
p.L382V	DO220854	MELA	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.6944
p.H382Y	DO232224	PBCA	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.6944
p.R379C	DO38567	STAD	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.8301
p.Q365R	DO38727	STAD	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.5278
p.V373A	KON	upper_aerodigestive_tract	COSMIC	PTPPMT	DEG_SCF_FBW7_1	0.3056
p.R370C	SNU-1040	large_intestine	COSMIC	PTPPMT	DEG_SCF_FBW7_1	0.2222
p.T366I	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPMT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NF64	Zinc finger MIZ domain-containing protein 2	DEG_SCF_FBW7_1	374:379	PTPPMT	FBXW7	0.9978	More...
Q9ULJ6	Zinc finger MIZ domain-containing protein 1	DEG_SCF_FBW7_1	516:521	PTPPMT	FBXW7	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons