DegronMD

Uniprot ID: Q9ULJ6

Source protein: Zinc finger MIZ domain-containing protein 1

Source gene: ZMIZ1

Class: DEG_SCF_FBW7_1

Location: 516:521

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 75.2

COIL: 0.9588

CONS_SCORE: 0.4008

DSS_SCORE: 0.6434

HELIX: 0.014

FCONS_SCORE: 1.057

RIG_SCORE: 0.5155

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P508A	TCGA-14-1396	GBM	TCGA	PTPPMT	DEG_SCF_FBW7_1	0.1111
p.P508A	DO11429	GBM	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.1111
p.Y529H	TCGA-24-2035	OV	TCGA	PTPPMT	DEG_SCF_FBW7_1	0.1111
p.Y529H	DO29598	OV	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.1111
p.Y529S	TCGA-24-2035	OV	TCGA	PTPPMT	DEG_SCF_FBW7_1	0.1111
p.Y529S	DO29598	OV	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.1111
p.G523W	TCGA-BF-A1PU	SKCM	TCGA	PTPPMT	DEG_SCF_FBW7_1	0.2778
p.G523W	DO50278	SKCM	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.2778
p.Y507C	TCGA-BR-4361	STAD	TCGA	PTPPMT	DEG_SCF_FBW7_1	0.0833
p.Y507C	DO38887	STAD	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.0833
p.N506T	TCGA-ER-A194	SKCM	TCGA	PTPPMT	DEG_SCF_FBW7_1	0.0556
p.N506T	DO47646	SKCM	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.0556
p.N506S	DO222998	BTCA	ICGC	PTPPMT	DEG_SCF_FBW7_1	0.0556
p.K516N	HOS	bone	COSMIC	PTPPMT	DEG_SCF_FBW7_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NF64	Zinc finger MIZ domain-containing protein 2	DEG_SCF_FBW7_1	374:379	PTPPMT	FBXW7	0.9978	More...
Q9ULJ6	Zinc finger MIZ domain-containing protein 1	DEG_SCF_FBW7_1	516:521	PTPPMT	FBXW7	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons