DegronMD - Q8NFF5(FLAD1)

FLAD1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I436L	TCGA-25-1313	OV	TCGA	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation rewiring degron network	0.25
p.I436L	DO28050	OV	ICGC	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation rewiring degron network	0.25
p.Q450L	TCGA-5C-A9VH	LIHC	TCGA	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation rewiring degron network	0.1667
p.Q450H	TCGA-DF-A2KN	UCEC	TCGA	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation rewiring degron network	0.1667
p.P441S	TCGA-ER-A198	SKCM	TCGA	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation altering degron motif	0.6752
p.P441S	DO47563	SKCM	ICGC	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation altering degron motif	0.6752
p.P441L	TCGA-ER-A198	SKCM	TCGA	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation altering degron motif	0.6471
p.F448L	TCGA-PK-A5HB	ACC	TCGA	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation rewiring degron network	0.2222
p.F448L	SIDM00526	Chronic Myelogenous Leukemia	GDSC	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation rewiring degron network	0.2222
p.F448L	MEG-01	haematopoietic and lymphoid tissue	COSMIC	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation rewiring degron network	0.2222
p.R437C	SIDM00844	Burkitt's Lymphoma	GDSC	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation rewiring degron network	0.2778
p.R433C	ACH-000963	Colon/Colorectal Cancer	CCLE	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation rewiring degron network	0.1667
p.R433C	CCK-81	large intestine	COSMIC	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation rewiring degron network	0.1667
p.R433H	MC116	haematopoietic and lymphoid tissue	COSMIC	ISPFPE	LIG_APCC_ABBA_1	439:444	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc