DegronMD

Uniprot ID: Q8NFF5

Source protein: FAD synthase

Source gene: FLAD1

Class: LIG_APCC_ABBA_1

Location: 439:444

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6353

ASA_SCORE: 77.7167

COIL: 0.764

CONS_SCORE: 0.4

DSS_SCORE: 0.0645

HELIX: 0.2153

FCONS_SCORE: 1.0899

RIG_SCORE: 0.7866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I436L	TCGA-25-1313	OV	TCGA	ISPFPE	LIG_APCC_ABBA_1	0.25
p.I436L	DO28050	OV	ICGC	ISPFPE	LIG_APCC_ABBA_1	0.25
p.Q450L	TCGA-5C-A9VH	LIHC	TCGA	ISPFPE	LIG_APCC_ABBA_1	0.1667
p.Q450H	TCGA-DF-A2KN	UCEC	TCGA	ISPFPE	LIG_APCC_ABBA_1	0.1667
p.P441S	TCGA-ER-A198	SKCM	TCGA	ISPFPE	LIG_APCC_ABBA_1	0.6752
p.P441S	DO47563	SKCM	ICGC	ISPFPE	LIG_APCC_ABBA_1	0.6752
p.P441L	TCGA-ER-A198	SKCM	TCGA	ISPFPE	LIG_APCC_ABBA_1	0.6471
p.F448L	TCGA-PK-A5HB	ACC	TCGA	ISPFPE	LIG_APCC_ABBA_1	0.2222
p.F448L	SIDM00526	Chronic Myelogenous Leukemia	GDSC	ISPFPE	LIG_APCC_ABBA_1	0.2222
p.F448L	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	ISPFPE	LIG_APCC_ABBA_1	0.2222
p.R437C	SIDM00844	Burkitt's Lymphoma	GDSC	ISPFPE	LIG_APCC_ABBA_1	0.2778
p.R433C	ACH-000963	Colon/Colorectal Cancer	CCLE	ISPFPE	LIG_APCC_ABBA_1	0.1667
p.R433C	CCK-81	large_intestine	COSMIC	ISPFPE	LIG_APCC_ABBA_1	0.1667
p.R433H	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	ISPFPE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFF5	FAD synthase	LIG_APCC_ABBA_1	439:444	ISPFPE	APC,CDC20,FZR1	0.6353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons