DegronMD - Q8NFI3(ENGASE)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E24Q	DO1273	BRCA	ICGC	RRRQLQGLA	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.6744
p.R25H	DO51634	CESC	ICGC	RRRQLQGLA	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.3056
p.R14M	DO228971	LICA	ICGC	RRRQLQGLA	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.T9N	DO233296	NACA	ICGC	RRRQLQGLA	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1389
p.R18P	SIDM00572	Gastric Carcinoma	GDSC	RRRQLQGLA	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.6401
p.R18P	SIDM00544	Neuroblastoma	GDSC	RRRQLQGLA	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.6401
p.A25S	ACH-000901	Lung Cancer	CCLE	RRRQLQGLA	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.3056
p.A25V	ACH-000901	Lung Cancer	CCLE	RRRQLQGLA	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.3056
p.A12T	ACH-000982	Colon/Colorectal Cancer	CCLE	RRRQLQGLA	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons