DegronMD

Uniprot ID: Q8NFI3

Source protein: Cytosolic endo-beta-N-acetylglucosaminidase

Source gene: ENGASE

Class: DEG_APCC_DBOX_1

Location: 16:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.885

ASA_SCORE: 106.3222

COIL: 0.4658

CONS_SCORE: 0.363

DSS_SCORE: 0.6913

HELIX: 0.5179

FCONS_SCORE: 0.9972

RIG_SCORE: 0.6781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E24Q	DO1273	BRCA	ICGC	RRRQLQGLA	DEG_APCC_DBOX_1	0.6744
p.R25H	DO51634	CESC	ICGC	RRRQLQGLA	DEG_APCC_DBOX_1	0.3056
p.R14M	DO228971	LICA	ICGC	RRRQLQGLA	DEG_APCC_DBOX_1	0.2778
p.T9N	DO233296	NACA	ICGC	RRRQLQGLA	DEG_APCC_DBOX_1	0.1389
p.R18P	SIDM00572	Gastric Carcinoma	GDSC	RRRQLQGLA	DEG_APCC_DBOX_1	0.6401
p.R18P	SIDM00544	Neuroblastoma	GDSC	RRRQLQGLA	DEG_APCC_DBOX_1	0.6401
p.A25S	ACH-000901	Lung Cancer	CCLE	RRRQLQGLA	DEG_APCC_DBOX_1	0.3056
p.A25V	ACH-000901	Lung Cancer	CCLE	RRRQLQGLA	DEG_APCC_DBOX_1	0.3056
p.A12T	ACH-000982	Colon/Colorectal Cancer	CCLE	RRRQLQGLA	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFI3	Cytosolic endo-beta-N-acetylglucosaminidase	DEG_APCC_DBOX_1	16:24	RRRQLQGLA	APC,CDC20,FZR1	0.885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons