DegronMD - Q8NFM7(IL17RD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R660W	TCGA-D1-A15X	UCEC	TCGA	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.3056
p.R660W	TCGA-DM-A0X9	COAD	TCGA	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.3056
p.R660W	SIDM01233	Colorectal Carcinoma	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.3056
p.R660W	ACH-000009	Colon/Colorectal Cancer	CCLE	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.3056
p.R660W	C2BBe1	large intestine	COSMIC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.3056
p.R660Q	TCGA-E5-A4TZ	BLCA	TCGA	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.3056
p.S691F	TCGA-QB-A6FS	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.1944
p.M658V	SIDM00308	Chronic Myelogenous Leukemia	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.25
p.M658V	SIDM00273	Glioblastoma	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.25
p.M658V	SIDM01695	Acute Myeloid Leukemia	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.25
p.M658V	SIDM00167	Head and Neck Carcinoma	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.25
p.A709V	SIDM00660	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.0833
p.A709V	ACH-000985	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.0833
p.A709V	LS-411N	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	696:700	Mutation rewiring degron network	0.0833
p.D657Y	SIDM00690	Head and Neck Carcinoma	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.2222
p.D657Y	ACH-002251	Head and Neck Cancer	CCLE	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.2222
p.D657Y	JHU-029	upper aerodigestive tract	COSMIC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.2222
p.S667L	SIDM00035	Thyroid Gland Carcinoma	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation altering degron motif	0.7667
p.S667L	ACH-000037	Sarcoma	CCLE	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation altering degron motif	0.7667
p.S667L	S-117	soft tissue	COSMIC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation altering degron motif	0.7667
p.D657N	SIDM00006	Other Solid Cancers	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.2222
p.D657N	ACH-001552	Skin Cancer	CCLE	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.2222
p.D657N	MCC26	skin	COSMIC	DSGIYDS	DEG_SCF_TRCP1_1	661:667	Mutation rewiring degron network	0.2222

Kaplan plot for IL17RD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL17RD

UniProt ID: Q8NFM7

Entrez ID: 54756

Protein name: Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (IL17Rhom) (Interleukin-17 receptor-like protein) (Sef homolog) (hSef)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL17RD in