DegronMD

Uniprot ID: Q8NFM7

Source protein: Interleukin-17 receptor D

Source gene: IL17RD

Class: DEG_SCF_TRCP1_1

Location: 661:667

E3 ligase: BTRC

DEGRON score: 0.998

ASA_SCORE: 72.9429

COIL: 0.7436

CONS_SCORE: 0.7305

DSS_SCORE: 0.6385

HELIX: 0.0886

FCONS_SCORE: 1.1639

RIG_SCORE: 0.6492

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R660W	TCGA-D1-A15X	UCEC	TCGA	DSGIYDS	DEG_SCF_TRCP1_1	0.3056
p.R660W	TCGA-DM-A0X9	COAD	TCGA	DSGIYDS	DEG_SCF_TRCP1_1	0.3056
p.R660W	SIDM01233	Colorectal Carcinoma	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	0.3056
p.R660W	ACH-000009	Colon/Colorectal Cancer	CCLE	DSGIYDS	DEG_SCF_TRCP1_1	0.3056
p.R660W	C2BBe1	large_intestine	COSMIC	DSGIYDS	DEG_SCF_TRCP1_1	0.3056
p.R660Q	TCGA-E5-A4TZ	BLCA	TCGA	DSGIYDS	DEG_SCF_TRCP1_1	0.3056
p.M658V	SIDM00308	Chronic Myelogenous Leukemia	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	0.25
p.M658V	SIDM00273	Glioblastoma	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	0.25
p.M658V	SIDM01695	Acute Myeloid Leukemia	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	0.25
p.M658V	SIDM00167	Head and Neck Carcinoma	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	0.25
p.D657Y	SIDM00690	Head and Neck Carcinoma	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	0.2222
p.D657Y	ACH-002251	Head and Neck Cancer	CCLE	DSGIYDS	DEG_SCF_TRCP1_1	0.2222
p.D657Y	JHU-029	upper_aerodigestive_tract	COSMIC	DSGIYDS	DEG_SCF_TRCP1_1	0.2222
p.S667L	SIDM00035	Thyroid Gland Carcinoma	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	0.7667
p.S667L	ACH-000037	Sarcoma	CCLE	DSGIYDS	DEG_SCF_TRCP1_1	0.7667
p.S667L	S-117	soft_tissue	COSMIC	DSGIYDS	DEG_SCF_TRCP1_1	0.7667
p.D657N	SIDM00006	Other Solid Cancers	GDSC	DSGIYDS	DEG_SCF_TRCP1_1	0.2222
p.D657N	ACH-001552	Skin Cancer	CCLE	DSGIYDS	DEG_SCF_TRCP1_1	0.2222
p.D657N	MCC26	skin	COSMIC	DSGIYDS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFM7	Interleukin-17 receptor D	DEG_SCF_TRCP1_1	661:667	DSGIYDS	BTRC	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons