DegronMD - Q8NFU1(BEST2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E440K	TCGA-FU-A40J	CESC	TCGA	SCSCAVVPEGA	DEG_COP1_1	432:442	Mutation altering degron motif	0.7022
p.E440K	DO44314	CESC	ICGC	SCSCAVVPEGA	DEG_COP1_1	432:442	Mutation altering degron motif	0.7022
p.S447R	DO10324	COAD	ICGC	SCSCAVVPEGA	DEG_COP1_1	432:442	Mutation rewiring degron network	0.1944
p.C423F	DO228974	LICA	ICGC	SCSCAVVPEGA	DEG_COP1_1	432:442	Mutation rewiring degron network	0.0833
p.S432R	DO46877	RECA	ICGC	SCSCAVVPEGA	DEG_COP1_1	432:442	Mutation altering degron motif	0.7427
p.A427V	ACH-000858	Lung Cancer	CCLE	SCSCAVVPEGA	DEG_COP1_1	432:442	Mutation rewiring degron network	0.1944
p.A443V	ACH-002005	Skin Cancer	CCLE	SCSCAVVPEGA	DEG_COP1_1	432:442	Mutation rewiring degron network	0.3056

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons