DegronMD

Uniprot ID: Q8NFU1

Source protein: Bestrophin-2

Source gene: BEST2

Class: DEG_COP1_1

Location: 432:442

E3 ligase: COP1

DEGRON score: 0.7888

ASA_SCORE: 74.2364

COIL: 0.8773

CONS_SCORE: 0.4453

DSS_SCORE: 0.095

HELIX: 0.0667

FCONS_SCORE: 1.0649

RIG_SCORE: 0.7308

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E440K	TCGA-FU-A40J	CESC	TCGA	SCSCAVVPEGA	DEG_COP1_1	0.7022
p.E440K	DO44314	CESC	ICGC	SCSCAVVPEGA	DEG_COP1_1	0.7022
p.S447R	DO10324	COAD	ICGC	SCSCAVVPEGA	DEG_COP1_1	0.1944
p.C423F	DO228974	LICA	ICGC	SCSCAVVPEGA	DEG_COP1_1	0.0833
p.S432R	DO46877	RECA	ICGC	SCSCAVVPEGA	DEG_COP1_1	0.7427
p.A427V	ACH-000858	Lung Cancer	CCLE	SCSCAVVPEGA	DEG_COP1_1	0.1944
p.A443V	ACH-002005	Skin Cancer	CCLE	SCSCAVVPEGA	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFU1	Bestrophin-2	DEG_COP1_1	432:442	SCSCAVVPEGA	COP1	0.7888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons