DegronMD - Q8NFU3(TSTD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R27S	DO229018	LICA	ICGC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.6316
p.D25E	DO229027	LICA	ICGC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.5647
p.T36N	DO229045	LICA	ICGC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.0833
p.R13C	DO222753	MELA	ICGC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1667
p.A17V	SIDM01178	Other Solid Cancers	GDSC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.A17V	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.F36L	OMC-1	cervix	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.0833
p.C26S	SK-N-AS	autonomic ganglia	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.7541
p.F24L	OMC-1	cervix	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.587
p.L22F	OMC-1	cervix	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.6981
p.E32K	FADU	upper aerodigestive tract	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.E20K	FADU	upper aerodigestive tract	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.7022
p.L34F	OMC-1	cervix	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons